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RNP-mediated CRISPR gene editing is becoming a new standard in gene and cell therapy. GenScript has developed hundreds of Cas9, Cas12a, Cas13a, MAD7, ABE, CBE, and prime editors for numerous gene editing companies. Plus, we have licensed a collection of validated GMP and RUO Grade catalog products from the Broad Institute.
GenScript’s custom Cas nuclease service delivers tailored enzymes across RUO to GMP—built to meet your exact editing goals. Backed by proprietary engineering platforms and rapid gene synthesis, we offer defined yield, purity, and activity—with guaranteed packages available. Projects can be completed in as little as 2 weeks, with regulatory support for IND submissions. From early discovery to therapeutic development, our custom solutions accelerate your CRISPR pipeline.
Guaranteed delivery
Yield and purity guaranteed
Industrial-leading Speed
As Fast as 2 weeks
Activity Assay Development
Established protocol with inhouse sgRNA & DNA substrate
Scale-up Capacity
Track record of GMP projects
| Cas nuclease variants | Base editor/Prime editor | |
|---|---|---|
| Amount | Guaranteed delivery of 500ug, 1mg, 5mg, 10mg, or 20mg | Guaranteed delivery of 500ug, 1mg, or 5mg |
| Tag | His tag | |
| QC Standard |
|
|
| Timeline | 2-4 weeks | |
GenScript’s catalog Cas nucleases offer high editing efficiency, low off-target rates, and broad cell type compatibility—ready to support both discovery and translational research. Our portfolio includes Cas9, Cas12a, Cas13a, Base Editors, and the industry’s first commercial Prime Editor. Each product is backed by rigorous QC, rapid delivery, and a proven GMP-ready pipeline. From knockout to precision correction, GenScript empowers your gene editing with reliability and speed.
Next-gen editing tools
First commercial Prime Editor available
Precision-focused
Low off-target variants for enhanced specificity
High Purity & Quality
Over 90% purity to ensure reliability and consistency
GMP Track Record
Supported 9 IMPD/IND filing
| Applications | Recommendations | Cat. No. | Product Names |
|---|---|---|---|
| Gene KO/KI with high editing efficiency | SpCas9 with NLS, his-tag (wt) | RC00001 | GenCRISPR™ NLS-wtSpCas9, his-tag |
| RC00002-GMP | GMP GenCRISPR™ NLS-wtSpCas9, his-tag | ||
| Gene KO/KI with low off-target effects | Ultra eSpCas9 (mt) | Z03622 | GenCRISPR™ Ultra eSpCas9-2NLS-Research |
| Z03624-GMP | GenCRISPR™ Ultra eSpCas9-2NLS-GMP | ||
| Gene KO/KI with lower MW Cas nucleases | LbCas12a | Z03753 | GenCRISPR™ LbCas12a Nuclease |
| RNA cleavage | LwaCas13a | Z03486 | GenCRISPR™ Cas13a (C2c2) Nuclease |
| Prime editingNew! | PE2 | RC00004 | GenCRISPR™ PE2 |
| PEmax | RC00005 | GenCRISPR™ PEmax | |
| PEmax Δ RNaseH | RC00003 | GenCRISPR™ PEmax RNase deletion | |
| PE6b | RC00006 | GenCRISPR™ PE6b | |
| PE6c | RC00007 | GenCRISPR™ PE6c | |
| PE6d | RC00008 | GenCRISPR™ PE6d | |
| PE7 | RC00009 | GenCRISPR™ PE7 | |
| Base editingNew! | ABE8e | RC00010 | GenCRISPR™ ABE8e |
Production of numerous base editors and prime editors
Base editors and prime editors are gaining more attention in gene editing era. However, their complex structures, including multiple protein and RNA components, make them challenging to express and purify.
At GenScript, we have successfully produced numerous base editors and prime editors both in high purity and decent yield.
Adenine base editor (ABE)
Cytosine base editor (CBE)
Prime editor (PE)
New! Off-the-shelf BE and PE are available here
| Type | ABE (TadA_nCas9) | CBE (APOBEC_nCas9) | PE (Cas9_RT) |
|---|---|---|---|
| Purification procedure |
|
|
|
| Purity | >90%, by SDS-PAGE under reducing conditions. | >90%, by SDS-PAGE under reducing conditions. | >90%, by SDS-PAGE under reducing conditions. |
| Yield | 1.6mg/L | 22.03mg/L | 12.3mg/L |
Customer Requirement: Deliver the Cas12a mutant and perform an activity assay
Delivery of the high purity Cas12a mutant
In vitro cleavage test result shows that the Cas12a mutant exhibits better cleavage activity than the wild type Cas12a
QC report
| Concentration by Bradford | Endotoxin | Purity by SDS-PAGE | Purity by SEC-HPLC | DNase detection | Amount |
|---|---|---|---|---|---|
| 4.93mg/mL | 0.648EU/mg | 90% | 94% | No detected | ~5mg |
In vitro cleavage test
Red arrow: Full-length
dsDNA substrate
Green arrow: Fragment-1 dsDNA
Blue arrow: Fragment-2 dsDNA
Customer Requirement:
Successfully delivered in 9 months
Test result shows that the Cas variant can induced deletion of target genome in all 3 host cells efficiently.
| Test items | Specifications | Results |
|---|---|---|
| Appearance | Clear, colorless liquid | PASS |
| Concentration | 10 ± 1 mg/mL | 9.5 mg/mL |
| Purity | >95% | 100% |
| Sterility | Negative | PASS |
| Endotoxin | < 0.5 EU/mg | < 0.25 EU/mg |
| Host Cell Protein | <50 ng/mg | 3.9 ng/mg |
| Residual DNase | < LOD | PASS |
| Residual RNase | < LOD | PASS |
| Host Cell DNA | <1 ng/mg | < 0.01 ng/mg |
Cas9 nuclease in vitro cleavage test
GenScript provides comprehensive solution for in vitro activity assays
Test result shows that the custom Cas9 produced by GenScript exhibited robust cleavage activity on target dsDNA
Red arrow: Full-length dsDNA
substrate
Green arrow: Fragment-1 dsDNA
Blue arrow: Fragment-2 dsDNA
"The people at GenScript have been tremendously helpful in providing materials for our lab. We've been able to test novel CRISPR systems such as prime editing and PASSIGE in a timely manner thanks to their work. I would recommend their services for your editing needs."
"We are very pleased with the editing efficiency using base editors from GenScript, we got up to 100% KO!"
SpCas9 Nuclease (wild-type)
Recombinant wild-type S. pyogenes Cas9 nucleases, purified from E. coli expression and contains various nuclear localization sequences (NLSs).
| Cat. No. | Product Name | Quantity | Price | Order |
|---|---|---|---|---|
|
RC00001
|
RC00001 |
|
$150.00 0.1 mg |
|
|
RC00002
|
GenCRISPR™ Ultra eSpCas9-2NLS-Research |
|
$10.00 1 mg |
|
|
Z03385
|
GenCrispr Cas9-C-NLS Nuclease |
|
$146.00 |
|
|
Z03386
|
GenCrispr Cas9 Nuclease |
|
$35.00 |
|
|
Z03388
|
GenCrispr Cas9-N-NLS Nuclease |
|
$146.00 |
|
|
Z03389
|
GenCrispr NLS-Cas9-NLS Nuclease |
|
$146.00 |
|
|
Z03468
|
GenCrispr Cas9-N-NLS Nuclease |
|
$188.00 |
|
|
Z03469
|
GenCrispr NLS-Cas9-NLS Nuclease |
|
$188.00 |
|
|
Z03621
|
GenCRISPR™ Ultra NLS-Cas9-Research |
|
$695.00 |
|
|
Z03623-GMP
|
GenCRISPR™ Ultra NLS-Cas9-GMP |
|
$6900.00 2.5 mg |
|
|
Z03702
|
GenCRISPR™ Cas9 v1.2 |
|
- 1 mg |
|
eSpCas9 Nuclease (mutant)
Recombinant mutant S. pyogenes Cas9 nucleases, purified from E. coli expression and contain various nuclear localization sequences (NLSs).
| Cat. No. | Product Name | Quantity | Price | Order |
|---|---|---|---|---|
|
Z03470
|
GenCrispr eSpCas9-N-NLS Nuclease |
|
$240.00 |
|
|
Z03622
|
GenCRISPR™ Ultra eSpCas9-2NLS-Research |
|
$765.00 |
|
Cas9-eGFP Nuclease
Recombinant S. pyogenes Cas9 nuclease and eGFP fusion protein, purified from E. coli expression, and contains nuclear localization sequence (NLS) and C-terminal 6xHis tag.
| Cat. No. | Product Name | Quantity | Price | Order |
|---|---|---|---|---|
|
Z03393
|
GenCrispr NLS-Cas9-EGFP Nuclease |
|
$188.00 |
|
|
Z03467
|
GenCrispr NLS-Cas9-EGFP Nuclease |
|
$241.00 |
|
SaCas9 Nuclease
Recombinant S. aureus Cas9 nuclease, purified from E. coli expression, and contains nuclear localization signals (NLSs) and no tag.
| Cat. No. | Product Name | Quantity | Price | Order |
|---|---|---|---|---|
|
Z03699
|
GenCRISPR™ SaCas9 2NLS Nuclease |
|
$210.00 |
|
Cas9 Nickase D10A
Recombinant S. pyogenes Cas9 Nickase D10A, purified from an E. coli strain expressing the protein, and contains nuclear localization sequences (NLSs).
| Cat. No. | Product Name | Quantity | Price | Order |
|---|---|---|---|---|
|
Z03390
|
GenCrispr NLS-Cas9-D10A Nickase |
|
$99.00 |
|
Cas12a Nuclease
Recombinant Acidaminococcus sp. (strain BV3L6) Cas12a (cpf1) nuclease or Lachnospiraceae bacterium ND2006 Cas12a nuclease, purified from E. coli expression, and contains nuclear localization sequences (NLSs).
| Cat. No. | Product Name | Quantity | Price | Order |
|---|---|---|---|---|
|
Z03502
|
GenCRISPR™ Cas12a (Cpf1) Nuclease |
|
$105.00 |
|
Cas13a Nuclease
Recombinant Leptotrichia wadei Cas13a nuclease or Leptotrichia buccalis Cas13a nuclease, purified from E. coli expression.
| Cat. No. | Product Name | Quantity | Price | Order |
|---|---|---|---|---|
|
Z03486
|
GenCRISPR™ Cas13a (C2c2) Nuclease |
|
$189.00 |
|
Prime editor
Base Editor
Your search returns no product results. Please explore our custom peptide synthesis solutions.
Gene Editing Kits
| Cat. No. | Product Name | Quantity | Price | Order |
|---|---|---|---|---|
|
L00688
|
GenCrispr Mutation Detection Kit |
|
$180.00 25 reactions |
|
|
L00689
|
GenCrispr sgRNA Screening Kit |
|
$166.00 30 reactions |
|
|
L00694
|
GenCrispr sgRNA Synthesis Kit |
|
$379.00 20 reactions |
|
|
Z03396
|
GenCrispr T7 Endonuclease I |
|
$55.00 |
|
Cas Nuclease Antibodies
| Cat. No. | Product Name | Quantity | Price | Order |
|---|---|---|---|---|
|
A01885
|
GenCrispr Cas9 Antibody, pAb, Rabbit |
|
$79.00 |
|
|
A01935
|
GenCRISPR™ SpCas9 Antibody (4A1), mAb, Mouse |
|
$99.00 40 μg |
|
|
A01936
|
GenCRISPR™ SpCas9 Antibody (14B6), mAb, Mouse |
|
$99.00 40 μg |
|
|
A01951
|
GenCRISPR™ SaCas9 Antibody (11C12), mAb, Mouse |
|
$99.00 40 μg |
|
|
A01952
|
GenCRISPR™ SaCas9 Antibody (26H10), mAb, Mouse |
|
$99.00 40 μg |
|
|
A01957
|
GenCRISPR™ FnCpf1 Antibody (9H6), mAb, Mouse |
|
$99.00 40 μg |
|
|
A01958
|
GenCRISPR™ FnCpf1 Antibody (14H3), mAb, Mouse |
|
$99.00 40 μg |
|
