Overview

RNP-mediated CRISPR gene editing is becoming a new standard in gene and cell therapy. GenScript has developed hundreds of Cas9, Cas12a, Cas13a, MAD7, ABE, CBE, and prime editors for numerous gene editing companies. Plus, we have licensed a collection of validated GMP and RUO Grade catalog products from the Broad Institute.

One-Stop Solution

Custom Cas Nuclease Service

GenScript’s custom Cas nuclease service delivers tailored enzymes across RUO to GMP—built to meet your exact editing goals. Backed by proprietary engineering platforms and rapid gene synthesis, we offer defined yield, purity, and activity—with guaranteed packages available. Projects can be completed in as little as 2 weeks, with regulatory support for IND submissions. From early discovery to therapeutic development, our custom solutions accelerate your CRISPR pipeline.

Service Highlights

Guaranteed delivery

Yield and purity guaranteed

Industrial-leading Speed

As Fast as 2 weeks

Activity Assay Development

Established protocol with inhouse sgRNA & DNA substrate

Scale-up Capacity

Track record of GMP projects

  • Service Details
    Guarantee Package Specification
    Cas nuclease variants Base editor/Prime editor
    Amount Guaranteed delivery of 500ug, 1mg, 5mg, 10mg, or 20mg Guaranteed delivery of 500ug, 1mg, or 5mg
    Tag His tag
    QC Standard
    • ≥90% purity by SDS-PAGE and SEC-HPLC
    • Concentration: 1-10mg/ml
    • <10EU /mg endotoxin
    • Nuclease removal
    Timeline 2-4 weeks

Cas Nuclease Catalog Products

GenScript’s catalog Cas nucleases offer high editing efficiency, low off-target rates, and broad cell type compatibility—ready to support both discovery and translational research. Our portfolio includes Cas9, Cas12a, Cas13a, Base Editors, and the industry’s first commercial Prime Editor. Each product is backed by rigorous QC, rapid delivery, and a proven GMP-ready pipeline. From knockout to precision correction, GenScript empowers your gene editing with reliability and speed.

Product Highlights

Next-gen editing tools

Next-gen editing tools

First commercial Prime Editor available

Precision-focused

Precision-focused

Low off-target variants for enhanced specificity

High Purity & Quality

High Purity & Quality

Over 90% purity to ensure reliability and consistency

Multiple Concentrations Available

GMP Track Record

Supported 9 IMPD/IND filing

  • Featured Products
    Applications Recommendations Cat. No. Product Names
    Gene KO/KI with high editing efficiency SpCas9 with NLS, his-tag (wt) RC00001 GenCRISPR™ NLS-wtSpCas9, his-tag
    RC00002-GMP GMP GenCRISPR™ NLS-wtSpCas9, his-tag
    Gene KO/KI with low off-target effects Ultra eSpCas9 (mt) Z03622 GenCRISPR™ Ultra eSpCas9-2NLS-Research
    Z03624-GMP GenCRISPR™ Ultra eSpCas9-2NLS-GMP
    Gene KO/KI with lower MW Cas nucleases LbCas12a Z03753 GenCRISPR™ LbCas12a Nuclease
    RNA cleavage LwaCas13a Z03486 GenCRISPR™ Cas13a (C2c2) Nuclease
    Prime editingNew! PE2 RC00004 GenCRISPR™ PE2
    PEmax RC00005 GenCRISPR™ PEmax
    PEmax Δ RNaseH RC00003 GenCRISPR™ PEmax RNase deletion
    PE6b RC00006 GenCRISPR™ PE6b
    PE6c RC00007 GenCRISPR™ PE6c
    PE6d RC00008 GenCRISPR™ PE6d
    PE7 RC00009 GenCRISPR™ PE7
    Base editingNew! ABE8e RC00010 GenCRISPR™ ABE8e

Case Studies

Related Products and Services

Testimonials

Browse All Cas Nuclease Product

SpCas9 Nuclease (wild-type)

Recombinant wild-type S. pyogenes Cas9 nucleases, purified from E. coli expression and contains various nuclear localization sequences (NLSs).

Cat. No. Product Name Quantity Price Order
RC00001
RC00001
$150.00 0.1 mg
 
RC00002
GenCRISPR™ Ultra eSpCas9-2NLS-Research
$10.00 1 mg
 
Z03385
GenCrispr Cas9-C-NLS Nuclease
$146.00
 
Z03386
GenCrispr Cas9 Nuclease
$35.00
 
Z03388
GenCrispr Cas9-N-NLS Nuclease
$146.00
 
Z03389
GenCrispr NLS-Cas9-NLS Nuclease
$146.00
 
Z03468
GenCrispr Cas9-N-NLS Nuclease
$188.00
 
Z03469
GenCrispr NLS-Cas9-NLS Nuclease
$188.00
 
Z03621
GenCRISPR™ Ultra NLS-Cas9-Research
$695.00
 
Z03623-GMP
GenCRISPR™ Ultra NLS-Cas9-GMP
$6900.00 2.5 mg
 
Z03702
GenCRISPR™ Cas9 v1.2
- 1 mg
 

eSpCas9 Nuclease (mutant)

Recombinant mutant S. pyogenes Cas9 nucleases, purified from E. coli expression and contain various nuclear localization sequences (NLSs).

Cat. No. Product Name Quantity Price Order
Z03470
GenCrispr eSpCas9-N-NLS Nuclease
$240.00
 
Z03622
GenCRISPR™ Ultra eSpCas9-2NLS-Research
$765.00
 

Cas9-eGFP Nuclease

Recombinant S. pyogenes Cas9 nuclease and eGFP fusion protein, purified from E. coli expression, and contains nuclear localization sequence (NLS) and C-terminal 6xHis tag. 

Cat. No. Product Name Quantity Price Order
Z03393
GenCrispr NLS-Cas9-EGFP Nuclease
$188.00
 
Z03467
GenCrispr NLS-Cas9-EGFP Nuclease
$241.00
 

SaCas9 Nuclease

Recombinant S. aureus Cas9 nuclease, purified from E. coli expression, and contains nuclear localization signals (NLSs) and no tag. 

Cat. No. Product Name Quantity Price Order
Z03699
GenCRISPR™ SaCas9 2NLS Nuclease
$210.00
 

Cas9 Nickase D10A

Recombinant S. pyogenes Cas9 Nickase D10A, purified from an E. coli strain expressing the protein, and contains nuclear localization sequences (NLSs).

Cat. No. Product Name Quantity Price Order
Z03390
GenCrispr NLS-Cas9-D10A Nickase
$99.00
 

Cas12a Nuclease

Recombinant Acidaminococcus sp. (strain BV3L6) Cas12a (cpf1) nuclease or Lachnospiraceae bacterium ND2006 Cas12a nuclease, purified from E. coli expression, and contains nuclear localization sequences (NLSs).

Cat. No. Product Name Quantity Price Order
Z03502
GenCRISPR™ Cas12a (Cpf1) Nuclease
$105.00
 

Cas13a Nuclease

Recombinant Leptotrichia wadei Cas13a nuclease or Leptotrichia buccalis Cas13a nuclease, purified from E. coli expression.

Cat. No. Product Name Quantity Price Order
Z03486
GenCRISPR™ Cas13a (C2c2) Nuclease
$189.00
 

Prime editor

Cat. No. Product Name Quantity Price Order
RC00004
ABE8e
$300.00 30 µg (3mg/ml)
 
RC00006
PE6b
-
 

Base Editor

Your search returns no product results. Please explore our custom peptide synthesis solutions.

Gene Editing Kits

Cat. No. Product Name Quantity Price Order
L00688
GenCrispr Mutation Detection Kit
$180.00 25 reactions
 
L00689
GenCrispr sgRNA Screening Kit
$166.00 30 reactions
 
L00694
GenCrispr sgRNA Synthesis Kit
$379.00 20 reactions
 
Z03396
GenCrispr T7 Endonuclease I
$55.00
 

Cas Nuclease Antibodies

Cat. No. Product Name Quantity Price Order
A01885
GenCrispr Cas9 Antibody, pAb, Rabbit
$79.00
 
A01935
GenCRISPR™ SpCas9 Antibody (4A1), mAb, Mouse
$99.00 40 μg
 
A01936
GenCRISPR™ SpCas9 Antibody (14B6), mAb, Mouse
$99.00 40 μg
 
A01951
GenCRISPR™ SaCas9 Antibody (11C12), mAb, Mouse
$99.00 40 μg
 
A01952
GenCRISPR™ SaCas9 Antibody (26H10), mAb, Mouse
$99.00 40 μg
 
A01957
GenCRISPR™ FnCpf1 Antibody (9H6), mAb, Mouse
$99.00 40 μg
 
A01958
GenCRISPR™ FnCpf1 Antibody (14H3), mAb, Mouse
$99.00 40 μg
 

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