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One unit of Benz-Neburase™ is capable of digesting 37μg of DNA in less than 30 minutes.
SEC-HPLC analysis of Benz-Neburase™ showed the enzyme at ≥ 99% purity.
Digest all forms of DNA and RNA.
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Figure 1. As the amount of Benz-Neburase increases, the viscosity of the sample gradually decreases, the supernatant gradually increases and becomes clear.
Figure 2. The test result show that Benz-Neburase can efficiently reduce cell clumping.
Figure 3. The test results indicate Benz-Neburase has minimal to no impact on the cell viability.
Figure 4. The test results show that Benz-Neburase can remove DNA and plasmid residue in virus production process. Fluorescence Activated Cell Sorting (FACS) was used to determine the functional titer of lentiviral particles. The analysis data indicate that the use of Benz-Neburase has minimal impact on the viral production recovery. The data further indicates that the GenScript Benz-Neburase outperforms the competitor product.
Figure 5. The test results show that Benz-Neburase can also remove DNA and plasmid residue in AAV virus production process more effectively than the competitor product. Viral genome (Vg) recovery was used to quantify the adeno associated viral production. The analysis data indicate that the use of Benz-Neburase has minimal impact on the viral production. The data further indicates that the GenScript Benz-Neburase outperforms the competitor product, while the Benz-Neburase GMP has comparative performance.
Benz-Neburase™ S. marcescens Nuclease Handbook
Introduction, advantages, and applications of Benz-Neburase™ S. marcescens Nuclease.
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