
10 BDs delivery of antibodies yields up to 1 g
Home » Protein Expression » TurboCHO™ or Nothing » TurboCHO™ Express Platform
GenScript has developed the proprietary TurboCHO™ expression system for higher-titer production of recombinant antibodies. Unlike TurboCHO™ High throughput platform, TurboCHO™ Express is designed for middle-scale production, with a timeline from gene synthesis to antibody delivery of just 10 business days! It also offers multiple purification and endotoxin control options in the default QC list, ensuring high-quality product delivery. TurboCHO™ Express platform can also deliver a range of purified antibody products (e.g., IgGs, Fab, scFV, VHH, bi-specific antibodies, and more) in quantities (i.e., from 5 mg to 1 g).
Additionally, GenScript introduces the FucoFree Cell line, designed for the production of afucosylated antibodies. This innovative cell line eliminates fucose modification, resulting in enhanced antibody-dependent cellular cytotoxicity (ADCC) and improved therapeutic efficacy. The combination of TurboCHO™ Express and the FucoFree Cell line provides researchers with efficient and tailored antibody production, offering new possibilities in the field of antibody therapeutics.
Cost-Effective
Superior Quality
Easy to Scale-up
FucoFree Cell Available
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Note: This customized solution applies to all
types of proteins, antibody species, isotypes, and fragments.
1. All incoming projects are subjected to evaluation.
2. Optional steps are offered with an extra charge upon
request.
3. The 10 business days is decided from sequence evaluation.
Bi-specific Antibody Production – Case 1, Titer: 374 mg/L with Purity > 99%
Bi-specific Antibody Production – Case 2, After purification yield: 65mg/L, Purity (SDS-Page)>95%, Purity (SEC)>93%
Bi-specific Antibody Production – Case 3, After purification yield: 98mg/L, Purity (SDS-Page)>90%, Purity (SEC)>99%
1. Similar expression performance in Fuco free TurboCHO system compared to wild-type TurboCHO!
No. | Control Titer (mg/L) | Fuco-free Titer (mg/L) | Titer Differences (%) |
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test-1 | 574 | 577 | 0.50% |
test-2 | 575 | 612 | 6.07% |
test-3 | 577 | 565 | -2.08% |
2. Comparable purity in Fuco free TurboCHO system compared to wild-type TurboCHO!
3. No fucosylation modification in Fuco free TurboCHO system compared to wild-type TurboCHO!
N-Glycan | G0F-GlcNAc | Man 5 | G0F | G1F |
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TurboCHO™ | 15.5% | 10.7% | 65.3% | 8.5% |
N-Glycan | G0-GlcNAc | Man 5 | G0 | G1 |
FucoFree TurboCHO™ | 15.0% | 8.9% | 71.2% | 4.9% |
From gene synthesis to antibody delivery starting at 8 BDs
Learn MoreDesigned for high-throughput screening, starting at 5 BDs
Learn MoreYield up to kg, from 6-7 weeks
Learn MoreHigh expression level with ECACC-licensed CHO-K1 cell
Learn MoreOne-stop solution for antibody drug development
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