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![IVT RNA Production Services]( "IVT RNA Production Services")
One Stop Solutions for IVT RNA
First in the market to achieve Gene-to-mRNA in just 3 weeks to drive innovations with our cutting-edge mRNA, circular RNA, and self-amplifying RNA technologies, seamlessly integrated with LNP delivery systems.
RNAs produced at GenScript are optimized with our proprietary production platform, ensuring the quality and expression efficiency.
Celebrate RNA Month this August: 30% off mRNA & LNP
—use code RNAMONTH30 (US only)Why GenScript
First to achieve Gene-to-mRNA in 3 weeks, driving your innovations with advanced mRNA, circular RNA, and self-amplifying RNA technologies, integrated with LNP delivery systems
Accelerate Discovery
Industry-leading 3-week turnaround time from Gene-to-mRNA for global customers
- Integrated capabilities from sequence design to RNA synthesis and LNP formulation in one solution
- Delivered > 4187 quality mRNA orders globally with 93% on-time delivery
Drive Innovation
Cutting-edge mRNA, circular RNA, and self-amplifying RNA technologies, seamlessly integrated with LNP delivery systems
- GenCap mRNA with high capping efficiency and UTR options
- Cap2 mRNA for better expression at stressed condition
- Circular RNA with enhanced circularization efficiency and high purity
- saRNA with reduced immunogenicity and high expression
Cultivate Collaboration
Proprietary & patented GenCap™ technologies open to licensing
Patented technologies covers:
- Co-transcriptional Capping Method
- Selection of UTRs for tissue specific targeting
- Optimized PolyA Vector
Highlights
One-Stop Solution for ALL Your mRNA Needs
GenScript’s solution to IVT mRNA manufacturing streamlines your workflow from gene synthesis to mRNA production. Our IVT mRNAs are optimized with our proprietary production platform, ensuring the quality and expression efficiency of your mRNA.
Codon/UTR
Optimization- Codon optimization for protein expression offered every day for every gene
- Codon optimization with >200 factors screened (patent)
Gene
Synthesis- 100 bp – 20 kb gene inserts
- TAT as fast as 6 BDs to 14 BDs
- Gene synthesis with Poly(A)-built-in vector
Cloning/Plasmid
Synthesis- Ready to use linearized plasmid DNA for IVT
- Vectors encoded stable Poly(A) tracts with variance of only +/- 5-10 nt
mRNA
Synthesis- Customized RUO to preclinical grade mRNA service (Patent)
- Advanced purification (Oligo dT, dsRNA removal) and variety of QC options
Lipid Nanoparticles
Delivery- Generic ionizable lipid formulation
- Load 0.1- 30mg of mRNA, siRNA, miRNA, DNA and sgRNA delivery
- LNP for gene editing
Comparison of different IVT RNA payload formats
Linear mRNA Self-Amplifying RNA Circular RNA 
Structure Linear; Open 5’ and 3’ end
mRNA exonuclease degradationLinear; Open 5’ and 3’ end
mRNA exonuclease degradationClose loop; No free 5’ 3’ end
Eliminating mRNA exonuclease degradationRibosome recruiting 5’ Cap:
Initiates translation & stabilizes mRNA5’ Cap:
Initiates translation & stabilizes mRNAInternal Ribosome Entry Site (IRES) :
Initiates translationORF - Codon optimization for translation yield
- Modified nucleosides, eg. M1Ψ
- Insert < 20 kb
- Codon optimization for translation yield
- Modified nucleosides, eg. M5C
- Insert < 6 kb
- Codon optimization for translation yield
- Insert < 4 kb
UTR Regulatory elements in the 5’ and 3’-UTR stabilize mRNA and increase translation initiation Replicon for further self-replication of the mRNA Include IRES + PIE + other elements PolyA tail Stabilizes RNA molecule & Prevents degradation Stabilizes RNA molecule & Prevents degradation Not required Protein Expression +++ Strong +++++ Strongest ++++ Stronger Expression half-life +++ Shorter +++++ Longest ++++ Longer Immunogenicity ++++ Low ++ High +++ Medium Dosage requirement ++ High +++++ Lowest +++ Medium Novelty +++ Traditional ++++ Novel +++++ Novel Testimonials
Dr. Sang-Moo Kang
Institute for Biomedical Sciences at Georgia State University
GenScript mRNA has helped us make a rapid progress in developing novel vaccine projects. GenScript's service is faithful and timely provided, saving me lots of time to focus on research. This is why I have been using GenScript services for over 20 years.
Resources
mRNA Case Study Report
Case studies showing high expression efficiency of GenScript’s mRNA for expressing SB transposase, GFP, Luciferase, eSpCas9, and more.
Free Download
Circular RNA Case Study Report
Circular RNA introduction, GenScript offering details, and case studies showing increased stability, prolonged expression, and lower immunogenicity compared to linear IVT mRNA.
Free Download
LNP Case Study Report
Case studies demonstrating encapsulation and delivery efficiency of GenScript’s new LNP formulations in cell models, and mouse models via both IM and IV.
Free Download
Critical Consideration in Sourcing mRNA_Whitepaper
This whitepaper provides valuable insights into the essential factors that vaccine and therapy developers should consider when exploring mRNA solutions
Free Download
Advancements in mRNA manufacturing_eBook
Get GenScript’s free application eBook on therapeutics development with mRNA manufacturing solutions
Free Download
mRNA Therapy Modalities_Infographic
Learn about key structural features and functions of IVT mRNA and LNP, therapeutic modalities beyond prophylactic vaccines, mRNA candidates progressing through clinical trials.
Free Download
mRNA Parts_Infographic
Learn about the main structural components of mRNA, the functional roles of each part, what constitutes high-quality IVT mRNA and more.
Free Download
Circular RNA Beginner’s Guide_Infographic
Learn about key structural components of circRNA, the process by which circRNA is translated into protein, and more.
Free Download
Self-Amplifying RNA Beginner’s Guide_Infographic
Learn about key structural components of saRNA, the processes by which saRNA replicates and is translated into protein, and more.
Free Download -
