Most Popular Products
CRISPR Gene Editing
Antibodies
ELISA Kits
Protein Electrophoresis and Blotting
Protein Purification
Proteins
Molecular Biology
Stable Cell Lines
Cell Therapy
Diagnostics
Resources
| Z03302 | |
|
|
|
| $75.00 | |
|
|
|
|
|
|
| Ask us a question | |
| Species | Rat | |
| Protein Construction |
|
|
| Purity | > 95% as analyzed by SDS-PAGE | |
| Endotoxin Level | < 0.2 EU/μg of protein by gel clotting method | |
| Biological Activity | The EC50 value of Rat NAP-2/CXCL7on Ca2+ mobilization assay in CHO-K1/Gα15/rCXCR2 cells (human Gα15 and Rat CXCR2 stably expressed in CHO-K1 cells) is less than 200.0 ng/ml. | |
| Expression System | E. coli | |
| Apparent Molecular Weight | ~6.9 kDa, on SDS-PAGE under reducing conditions. | |
| Formulation | Lyophilized after extensive dialysis against PBS. | |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml. | |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
| Target Background | Neutrophil Activating Peptide 2 (NAP-2) is proteolytically processed carboxyl-terminal fragments of platelet basic protein (PBP) which is found in the alpha-granules of human platelets. NAP-2 is a member of the CXC chemokines. Similar to other ELR domain containing CXC chemokines such as IL-8 and the GRO proteins, NAP-2 has been shown to bind CXCR-2 and to chemoattract and activate neutrophils. Although CTAP-III, β-TG and PBP represent amino-terminal extended variants of NAP-2 and possess the same CXC chemokine domains, these proteins do not exhibit NAP-2 activity. Recently, it has been shown that the additional amino-terminal residues of CTAP-III masks the critical ELR receptor binding domain that is exposed on NAP-2 and may account for lack of NAP-2 activity. |
| Synonyms | PPBP; B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII; CXCL-7; LA-PF4; LDGF; MDGF; NAP2; PBP; SCYB7; TC1; TC2; TGB; TGB1; THBGB; THBGB1; pro-platelet basic protein |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
