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| Z02943 | |
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| $70.00 | |
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| Ask us a question | |
| Species | Mouse | |
| Protein Construction |
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| Purity |
> 97% as analyzed by SDS-PAGE > 97% as analyzed by HPLC |
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| Endotoxin Level | < 1 EU/μg of protein by LAL method | |
| Biological Activity | Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 1.0 ng/ml, corresponding to a specific activity of > 1.0 × 106 IU/mg. | |
| Expression System | E. coli | |
| Theoretical Molecular Weight | 9.8 kDa | |
| Formulation | Lyophilized from a 0.2 μm filtered solution in 10 mM PB, 500 mM NaCl, pH7.4. | |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. | |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
| Target Background | Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins. HB-EGF-like growth factor is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein. An epidermal growth factor produced by monocytes and macrophages, due to an affinity for heparin is termed HB-EGF. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function. The transmembrane form of HB-EGF is the unique receptor for diptheria toxin and functions in juxtacrine signaling in cells. Both forms of HB-EGF participate in normal physiological processes and in pathological processes including tumor progression and metastasis, organ hyperplasia, and atherosclerotic disease. HB-EGF can bind two locations on cell surfaces, heparan sulfate proteoglycans and EGF-receptor effecting cell to cell interactions. |
| Synonyms | HEGFL; Heparin Binding EGF-like growth factor; HBEGF; Diphtheria toxin receptor; DTR |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
