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About the Class A/1 (Rhodopsin-like receptors) pathway
Rhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and thus, can be subdivided into 19 subfamilies (Subfamily A1-19) based on a phylogenetic analysis (Joost P and Methner A, 2002).
The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.
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Gene Symbol | Full Name |
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ADORA1 | adenosine A1 receptor |
ADORA2A | adenosine A2a receptor |
ADORA2B | adenosine A2b receptor |
ADORA3 | adenosine A3 receptor |
ADRA1D | adrenoceptor alpha 1D |
ADRA1B | adrenoceptor alpha 1B |
ADRA1A | adrenoceptor alpha 1A |
ADRA2A | adrenoceptor alpha 2A |
ADRA2B | adrenoceptor alpha 2B |
ADRA2C | adrenoceptor alpha 2C |
ADRB1 | adrenoceptor beta 1 |
ADRB2 | adrenoceptor beta 2, surface |
ADRB3 | adrenoceptor beta 3 |
AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
AGTR1 | angiotensin II receptor, type 1 |
AGTR2 | angiotensin II receptor, type 2 |
APLNR | apelin receptor |
ANXA1 | annexin A1 |
APP | amyloid beta (A4) precursor protein |
AVP | arginine vasopressin |
AVPR1A | arginine vasopressin receptor 1A |
AVPR1B | arginine vasopressin receptor 1B |
AVPR2 | arginine vasopressin receptor 2 |
OPN1SW | opsin 1 (cone pigments), short-wave-sensitive |
BDKRB1 | bradykinin receptor B1 |
BDKRB2 | bradykinin receptor B2 |
CXCR5 | chemokine (C-X-C motif) receptor 5 |
BRS3 | bombesin-like receptor 3 |
C3 | complement component 3 |
C3AR1 | complement component 3a receptor 1 |
C5 | complement component 5 |
C5AR1 | complement component 5a receptor 1 |
CCK | cholecystokinin |
CCKAR | cholecystokinin A receptor |
CCKBR | cholecystokinin B receptor |
CGA | glycoprotein hormones, alpha polypeptide |
CHRM1 | cholinergic receptor, muscarinic 1 |
CHRM2 | cholinergic receptor, muscarinic 2 |
CHRM3 | cholinergic receptor, muscarinic 3 |
CHRM4 | cholinergic receptor, muscarinic 4 |
CHRM5 | cholinergic receptor, muscarinic 5 |
CCR1 | chemokine (C-C motif) receptor 1 |
CCR3 | chemokine (C-C motif) receptor 3 |
CCR4 | chemokine (C-C motif) receptor 4 |
CCR5 | chemokine (C-C motif) receptor 5 (gene/pseudogene) |
CCR6 | chemokine (C-C motif) receptor 6 |
CCR7 | chemokine (C-C motif) receptor 7 |
CCR8 | chemokine (C-C motif) receptor 8 |
ACKR2 | atypical chemokine receptor 2 |
LTB4R | leukotriene B4 receptor |
CNR1 | cannabinoid receptor 1 (brain) |
CNR2 | cannabinoid receptor 2 (macrophage) |
CX3CR1 | chemokine (C-X3-C motif) receptor 1 |
DRD1 | dopamine receptor D1 |
DRD2 | dopamine receptor D2 |
DRD3 | dopamine receptor D3 |
DRD4 | dopamine receptor D4 |
DRD5 | dopamine receptor D5 |
S1PR1 | sphingosine-1-phosphate receptor 1 |
LPAR1 | lysophosphatidic acid receptor 1 |
S1PR3 | sphingosine-1-phosphate receptor 3 |
EDN1 | endothelin 1 |
EDN2 | endothelin 2 |
EDN3 | endothelin 3 |
EDNRA | endothelin receptor type A |
EDNRB | endothelin receptor type B |
F2 | coagulation factor II (thrombin) |
F2R | coagulation factor II (thrombin) receptor |
F2RL1 | coagulation factor II (thrombin) receptor-like 1 |
F2RL2 | coagulation factor II (thrombin) receptor-like 2 |
FPR1 | formyl peptide receptor 1 |
FPR2 | formyl peptide receptor 2 |
FPR3 | formyl peptide receptor 3 |
FSHB | follicle stimulating hormone, beta polypeptide |
FSHR | follicle stimulating hormone receptor |
ACKR1 | atypical chemokine receptor 1 (Duffy blood group) |
GALR1 | galanin receptor 1 |
OPN1MW | opsin 1 (cone pigments), medium-wave-sensitive |
GHSR | growth hormone secretagogue receptor |
GNRH1 | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) |
GNRH2 | gonadotropin-releasing hormone 2 |
GNRHR | gonadotropin-releasing hormone receptor |
CCR10 | chemokine (C-C motif) receptor 10 |
GPR4 | G protein-coupled receptor 4 |
XCR1 | chemokine (C motif) receptor 1 |
NPBWR1 | neuropeptides B/W receptor 1 |
NPBWR2 | neuropeptides B/W receptor 2 |
CXCR3 | chemokine (C-X-C motif) receptor 3 |
PRLHR | prolactin releasing hormone receptor |
UTS2R | urotensin 2 receptor |
GPR17 | G protein-coupled receptor 17 |
GPR18 | G protein-coupled receptor 18 |
LPAR4 | lysophosphatidic acid receptor 4 |
MCHR1 | melanin-concentrating hormone receptor 1 |
GPER1 | G protein-coupled estrogen receptor 1 |
GPR31 | G protein-coupled receptor 31 |
GPR37 | G protein-coupled receptor 37 (endothelin receptor type B-like) |
MLNR | motilin receptor |
GPR39 | G protein-coupled receptor 39 |
FFAR1 | free fatty acid receptor 1 |