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altered-self hypothesis

The proposal that helper T-cells recognize a foreign material, e.g. a viral antigen, when it is presented on the surface of an antigen-presenting cell as a complex with the major histocompatibility complex (MHC) class II glycoprotein. This is contrasted with a less favoured explanation, the intimacy or dual-recognition model, which postulates that helper T-cells must simultaneously recognize both the foreign antigen and the separate MHC complex. By a simple extension, the altered-self hypothesis further proposes that a chemically altered MHC may also be recognized by helper T-cells.

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