siRNA Guarantee Package

Precise Design, Superior Quality
Guaranteed Knockdown Efficiency (KD%) ≥80%

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Overview

The design of siRNA is crucial for effective gene silencing. Choose GenScript’s guarantee package, powered by machine learning, to maximize your success.

Advantages

AI-Enhanced design ensures higher knockdown efficiency

Guaranteed knockdown efficiency ≥80%
Experimentally-verified knockdown efficiency up to 98%

22 years of expertise in nucleic
acids, offering superior quality

Accurate molecular weight, high purity,
stable batches improve experimental success and consistency

Transfection to detection in just 4 days

Fast and cost-effective, with available qPCR probes/primers
for knockdown efficiency detection

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Oligo Synthesis

Service Details

Service Type	Deliverables	Purification	Delivery Format	Price	Production Time
Standard Package	3 siRNAs per gene : 5 nmol* / each pair siRNA Nuclease-free water: 1 mL	RNase free HPLC grade (Purity ≥90%)	Annealed double-strand (default) Dry powder (default) TE buffer / Nuclease-free water / Annealing buffer (Optional)	$291	4 business days
Premium Package	3 siRNAs per gene : 5 nmol* / each pair siRNA Nuclease-free water: 1 mL 1 positive control^#: 2nmol* 1 negative control^#: 2nmol*			$591
Add-on Service	Positive control^# (GAPDH or ACTB): 2 nmol			$180
Add-on Service	Negative control^#: 2 nmol			$120

^# Mouse and human species are available for positive and negative controls.
* For other delivery quantities, please inquire for details.

Guarantee Rules:
a) We guarantee 1 out of 3 siRNA will show a knock down efficiency (KD%) in mRNA level over 80% at a concentration of 25 nM in 48h. Demonstrate that the positive control’s KD% is ≥80% to confirm the experimental system's validity.
b) If this is not observed, please provide the protocol & data to us , we will provide a one-time replacement siRNA for free with noshipping fee.
c) Limited to naked siRNA for human, mouse, rat species in vitro.
How to order? Download the quote form and fill in the necessary information for your request. Send the quote form to your Technical Account Manager or to oligo@genscript.com.

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Add-on Services

After siRNA transfection, qPCR probes and primers are used to evaluate silencing efficiency by measuring target mRNA levels. GenScript offers these tools, with options to use your own sequences or have them designed. To streamline your experiment, consider ordering the siRNA synthesis and qPCR detection reagents together for delivery in 4 working days.

Applications	Services	Specifications	Quantity	Purification	Production Time
Positive control detection*	TaqMan Probe	16-25 nt, BHQ1/MGB modification	1-20 nmol	HPLC grade	4 business days
Positive control detection*	Primers	18-28 nt
Target gene detection*	TaqMan Probe	16-25 nt, BHQ1/MGB modification
Target gene detection*	Primers	18-28 nt

* Free sequence design for positive control qPCR probes/primers is available. Use https://www.ncbi.nlm.nih.gov/tools/primer-blast/ for target gene design. GenScript design incurs extra fees and adds one day. # Custom lengths, quantities, and modifications available. Inquire for details.

Case Studies

siRNA showed high knockdown efficiency for various genes
- At least 1 siRNA exhibited knockdown efficiency (KD%) of over 80% in 4 different tested genes
- siRNA designed with GenScript’s design platform exhibits higher KD% efficiency than those designed with other platforms
The positive control siRNA from GenScript achieved a knockdown efficiency of up to 99%
GenScript's designed positive controls have been validated for high knockdown efficiency:
- Human ACTB: up to 99% / Human GAPDH: up to 99%
- Mouse ACTB: up to 91%