Gene Symbol | TLR4 |
Entrez Gene ID | 554263 |
Full Name | toll like receptor 4 |
Gene Type | protein-coding |
Organism | Ovis aries(sheep) |
ORF » Species Summary » Ovis aries » TLR4 cDNA ORF clone
Gene Symbol | TLR4 |
Entrez Gene ID | 554263 |
Full Name | toll like receptor 4 |
Gene Type | protein-coding |
Organism | Ovis aries(sheep) |
mRNA | Protein | Name |
---|---|---|
XM_027963892.1 | XP_027819693.1 | toll-like receptor 4 isoform X1 |
XM_012111214.2 | XP_011966604.2 | toll-like receptor 4 isoform X1 |
NM_001135930.1 | NP_001129402.1 | toll-like receptor 4 precursor |
XM_012111214.1 | XP_011966604.1 | toll-like receptor 4 isoform X1 |
Overexpression of Toll-like receptor 4 enhances LPS-induced inflammatory response and inhibits Salmonella Typhimurium growth in ovine macrophages.
Wei S, Yang D, Yang J, Zhang X, Zhang J, Fu J, Zhou G, Liu H, Lian Z, Han H
European journal of cell biology98(1)36-50(2019 Jan)
Lipopolysaccharides belonging to different Salmonella serovars are differentially capable of activating Toll-like receptor 4.
Chessa D, Spiga L, De Riu N, Delaconi P, Mazzarello V, Ganau G, Rubino S
Infection and immunity82(11)4553-62(2014 Nov)
Up-regulation of Toll-like receptor 4/nuclear factor-kappaB signaling is associated with enhanced adipogenesis and insulin resistance in fetal skeletal muscle of obese sheep at late gestation.
Yan X, Zhu MJ, Xu W, Tong JF, Ford SP, Nathanielsz PW, Du M
Endocrinology151(1)380-7(2010 Jan)
Molecular cloning and characterization of Toll-like receptors 1-10 in sheep.
Chang JS, Russell GC, Jann O, Glass EJ, Werling D, Haig DM
Veterinary immunology and immunopathology127(1-2)94-105(2009 Jan)
Toll-like receptors and agonist responses in the developing fetal sheep lung.
Hillman NH, Moss TJ, Nitsos I, Kramer BW, Bachurski CJ, Ikegami M, Jobe AH, Kallapur SG
Pediatric research63(4)388-93(2008 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following TLR4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TLR4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSm21198 | |
Clone ID Related Accession (Same CDS sequence) | NM_001135930.1 | |
Accession Version | NM_001135930.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2523bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 1552233600000 | |
Organism | Ovis aries(sheep) | |
Product | toll-like receptor 4 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AM981302.1. ##Evidence-Data-START## Transcript exon combination :: AM981302.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA104494983, SAMEA104494984 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCGCGTG CCCGCCGGGC TGCGGCTCTG ATCCCGGCCA TGGCCATCCT CTCCTGCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001129402.1 |
CDS | 4..2526 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCGCGTG CCCGCCGGGC TGCGGCTCTG ATCCCGGCCA TGGCCATCCT CTCCTGCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OSm21969 | |
Clone ID Related Accession (Same CDS sequence) | XM_012111214.1 | |
Accession Version | XM_012111214.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 1450195200000 | |
Organism | Ovis aries(sheep) | |
Product | toll-like receptor 4 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_014639011.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Ovis aries Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCCCTAC TCAACCTCTC TTTAGATTTG TCCCTGAACC CTTTAGAATT TATTGAACCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011966604.1 |
CDS | 814..2739 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCCCTAC TCAACCTCTC TTTAGATTTG TCCCTGAACC CTTTAGAATT TATTGAACCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OSm69143 | |
Clone ID Related Accession (Same CDS sequence) | XM_027963892.1 , XM_012111214.2 | |
Accession Version | XM_027963892.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 1549296000000 | |
Organism | Ovis aries(sheep) | |
Product | toll-like receptor 4 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_040253.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Ovis aries Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCCCTAC TCAACCTCTC TTTAGATTTG TCCCTGAACC CTTTAGAATT TATTGAACCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_027819693.1 |
CDS | 429..2354 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCCCTAC TCAACCTCTC TTTAGATTTG TCCCTGAACC CTTTAGAATT TATTGAACCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OSm69143 | |
Clone ID Related Accession (Same CDS sequence) | XM_027963892.1 , XM_012111214.2 | |
Accession Version | XM_012111214.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 1549296000000 | |
Organism | Ovis aries(sheep) | |
Product | toll-like receptor 4 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_040253.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 6, 2019 this sequence version replaced XM_012111214.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Ovis aries Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCCCTAC TCAACCTCTC TTTAGATTTG TCCCTGAACC CTTTAGAATT TATTGAACCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011966604.2 |
CDS | 814..2739 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCCCTAC TCAACCTCTC TTTAGATTTG TCCCTGAACC CTTTAGAATT TATTGAACCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Overexpression of Toll-like receptor 4 enhances LPS-induced inflammatory response and inhibits Salmonella Typhimurium growth in ovine macrophages. |
Lipopolysaccharides belonging to different Salmonella serovars are differentially capable of activating Toll-like receptor 4. |
Up-regulation of Toll-like receptor 4/nuclear factor-kappaB signaling is associated with enhanced adipogenesis and insulin resistance in fetal skeletal muscle of obese sheep at late gestation. |
Molecular cloning and characterization of Toll-like receptors 1-10 in sheep. |
Toll-like receptors and agonist responses in the developing fetal sheep lung. |