Hrc cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hrc
Entrez Gene ID	15464
Full Name	histidine rich calcium binding protein
General protein information	Preferred Names histidine rich calcium binding protein Names sarcoplasmic reticulum histidine-rich calcium-binding protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 B3\|7 29.26 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010473.2	NP_034603.2	sarcoplasmic reticulum histidine-rich calcium-binding protein precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Hrc	NP_034603.2
Canis lupus familiaris (dog)	HRC	XP_005616385.1
Rattus norvegicus (Norway rat)	Hrc	NP_852034.1
Macaca mulatta (Rhesus monkey)	HRC	XP_001114707.2

Gene Ontology
Bibliography

Related articles in PubMed

Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant.
Tzimas C, Johnson DM, Santiago DJ, Vafiadaki E, Arvanitis DA, Davos CH, Varela A, Athanasiadis NC, Dimitriou C, Katsimpoulas M, Sonntag S, Kryzhanovska M, Shmerling D, Lehnart SE, Sipido KR, Kranias EG, Sanoudou D
Cardiovascular research113(11)1403-1417(2017 Sep)

Characterization of Ca(2+)-Dependent Protein-Protein Interactions within the Ca(2+) Release Units of Cardiac Sarcoplasmic Reticulum.
Rani S, Park CS, Sreenivasaiah PK, Kim DH
Molecules and cells39(2)149-55(2016 02)

Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT.
Liu B, Ho HT, Brunello L, Unudurthi SD, Lou Q, Belevych AE, Qian L, Kim DH, Cho C, Janssen PM, Hund TJ, Knollmann BC, Kranias EG, Györke S
Cardiovascular research108(2)299-311(2015 11)

Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress.
Park CS, Chen S, Lee H, Cha H, Oh JG, Hong S, Han P, Ginsburg KS, Jin S, Park I, Singh VP, Wang HS, Franzini-Armstrong C, Park WJ, Bers DM, Kranias EG, Cho C, Kim DH
Basic research in cardiology108(3)344(2013 May)

Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase.
Arvanitis DA, Vafiadaki E, Fan GC, Mitton BA, Gregory KN, Del Monte F, Kontrogianni-Konstantopoulos A, Sanoudou D, Kranias EG
American journal of physiology. Heart and circulatory physiology293(3)H1581-9(2007 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Hrc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hrc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06227	NM_010473.2 Latest version!	Mus musculus histidine rich calcium binding protein (Hrc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hrc ( NM_010473.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034603.2 Mus musculus histidine rich calcium binding protein (Hrc), mRNA.

Price & Availability↑

CloneID	OMu06227
Clone ID Related Accession (Same CDS sequence)	NM_010473.2
Accession Version	NM_010473.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2217bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1527177600000
Organism	Mus musculus(house mouse)
Product	sarcoplasmic reticulum histidine-rich calcium-binding protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC150897.2, AF132218.1 and AI322629.1. On Mar 20, 2007 this sequence version replaced NM_010473.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX523625.1, AF132218.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCTTCC AGGGGCCATG GTTGCACACT TGTCTCCTTT GGGCCACAGT GGCCATCCTG 
CTGGTCCCTC CAGTGGTGAC CCAGGAGTTG AGAGGGGCCG GTCTGGGCCT GGGCAACTGG 
AACAACAATG CAGGCATCCC TGGGTCCTCA GAGGACCTAT CAACTGAGTT TGGTCACCAC 
ATCCACCGGG GATATCAAGG TGAGAAGGAC AGAGGCCACA GAGAAGAGGG TGAAGACTTC 
TCCAGGGAAT ATGGCCACAG GGTCCAAGAC CACAGGTACC CTGGCCGCGA GGTTGGAGAG 
GAGAATGTCT CTGAAGAGGT CTTCAGAGGG CATGTTAGAC AGCTCCACGG GCACCGGGAA 
CATGACAATG AAGATTTAGG AGACTCGGCA GAGAACCACC TCCCCAGACA GAGGAGCCAC 
AGCCACGAAG ATGAGGATGG CATTGTCTCC AGTGAGTATC ACCGTCACGT CCCCAGGCAT 
GCCCACCATG GCCACGGAGA GGAAGATGAT GACGATGATG GAGGAGAGGA GGAGGAGAGG 
GTGGATGTGA TGGAGGACTC TGATGATAAT GAACACCAGG TCCATGGTCA CCAGAGCCAC 
TCAAAGGAGA GAGATGAACT CCATCATGCC CACAGCCACA GGCACCAAGG CCACAGTGAT 
GATGACGATG ACGATGGTGT CTCTACTGAG CATGGACACC AAGCTCACAG ATATCAGGAT 
CATGAGGAGG AAGACGATGG GGACTCAGAT GAAGACAGTC ACACCCACAG AGTTCAAGGC 
CGAGAAGATG AAAATGATGA TGAAGACGGT GACTCTGGTG AATACAGACA CCATACCCAG 
GACCACCAAG GCCACAACGA AGAGCAAGAT GACGATGATG ATGATGATGA TGATGATGAA 
GATAAAGAAG ACTCCACTGA GCACCGGCAC CAGACCCAAG GCCACAGGAA GGAAGAAGAT 
GAGGATGAGT CAGATGAAGA TGATCATCAT GTCTCCAGGC ATGGACGCCA AGGCTATGAA 
GAAGAAGAAG ATGATGATGA TGATGATGGA GATGATGACT CTACTGAGCA TGTGCATCAA 
GCCCACAGAC ACAGAGACCA TGAGCACAAA GATGATGAGG ATGACTCAGA AGAAGACTAC 
CATCATGTCC CCAGCCATGG CCGCCAAAGC CACCAAAATG AGGAAGAGGA AGATGAGGCT 
GTATCCACTG AACACTGGCA CCAGTCTCCT AGACATGCTC ACCATGATCT TGGACGTGAG 
AGTGAAGAAG AGGTAGCAGT CAAGTACAGC CACCATGTTG CAAGCCACCG TCCCCAAGGC 
CACAATGCTG ACAGGGAGGA GGACTCTCTA GAAGAACACA TGAATGAAGT CCCAGGCCAT 
CACCACCACA GAGCCTCCAG GGGTGATGAT GAGGACATTT CTACTGAGTT TGGCCACAAG 
GCCCCCAGCC ACAGGCTACA AGATCAAGAT GAAAGGGCGA GGCAGGGTCA CAGAGAGCCT 
GTTCAGGGAG AGATTGCTCA TCAGCCCCTG CAACCCACAG GACCCAGTTC AAGAGAATCA 
AGGAAGGAAG GTGACCACAG CTCTCAAGAG GGAGATGAAG ACCCAGAGCA GAGGCAAGCC 
CATAGTGAGG AGGAGAAGGA GGAGGAGGAG GAGGAGGAGG AGGAGGAGGA GGAGGAGAAA 
GAGGGGGGCC ATAGCCTCCC CATGAGCCAG GAAGATGATG AAGAGGAAGA AAAAGATGAG 
AAAGAAAGCA AGGTAGACAG GGCTGCAGTT TCAGCTCCAC TGAGCCATCA TAGGAAGCAG 
GGGGAGGAAG AGGAGGAGGA AGAGGAGGAG GAAGAGGAGG AGATCCTGGA GGAAAACCTA 
CTACCTTTCA CCATTATCCC AAACCCACTC GCTGGGAGAG AGGTGGCCAG AGAAGGTTCC 
AGTGAAGAGG AGAGCCGTGA GGTCACAGGT CAGCAGGATG CCCAGGAGTA CGAAAATTAC 
CAGCCAGGGT CTTTGTGTGG CTACTGTTCT TTCTGCAACC GATGTACCGA ATGTGAAAGC 
TGTCACTGTG ATGAGGAGAA CATGGGGGAA CACTGTGACC AGTGTCAGCA CTGTCAATTC 
TGCTACCTCT GTCCGCTGGT GTGTGACACG CTCTGCACTC CAGGAAGCTA CGTTGACTAT 
TTCTCCTCCT CTCTGTATCA AGCCCTGGCT GACATGTTGG AGACTCCAGA GCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034603.2
CDS	159..2375
Translation	MGFQGPWLHTCLLWATVAILLVPPVVTQELRGAGLGLGNWNNNAGIPGSSEDLSTEFGHHIHRGYQGEKDRGHREEGEDFSREYGHRVQDHRYPGREVGEENVSEEVFRGHVRQLHGHREHDNEDLGDSAENHLPRQRSHSHEDEDGIVSSEYHRHVPRHAHHGHGEEDDDDDGGEEEERVDVMEDSDDNEHQVHGHQSHSKERDELHHAHSHRHQGHSDDDDDDGVSTEHGHQAHRYQDHEEEDDGDSDEDSHTHRVQGREDENDDEDGDSGEYRHHTQDHQGHNEEQDDDDDDDDDDEDKEDSTEHRHQTQGHRKEEDEDESDEDDHHVSRHGRQGYEEEEDDDDDDGDDDSTEHVHQAHRHRDHEHKDDEDDSEEDYHHVPSHGRQSHQNEEEEDEAVSTEHWHQSPRHAHHDLGRESEEEVAVKYSHHVASHRPQGHNADREEDSLEEHMNEVPGHHHHRASRGDDEDISTEFGHKAPSHRLQDQDERARQGHREPVQGEIAHQPLQPTGPSSRESRKEGDHSSQEGDEDPEQRQAHSEEEKEEEEEEEEEEEEEKEGGHSLPMSQEDDEEEEKDEKESKVDRAAVSAPLSHHRKQGEEEEEEEEEEEEEILEENLLPFTIIPNPLAGREVAREGSSEEESREVTGQQDAQEYENYQPGSLCGYCSFCNRCTECESCHCDEENMGEHCDQCQHCQFCYLCPLVCDTLCTPGSYVDYFSSSLYQALADMLETPEP

Target ORF information:

RefSeq Version	NM_010473.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus histidine rich calcium binding protein (Hrc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010473.2

ORF Insert Sequence:

ATGGGCTTCC AGGGGCCATG GTTGCACACT TGTCTCCTTT GGGCCACAGT GGCCATCCTG 
CTGGTCCCTC CAGTGGTGAC CCAGGAGTTG AGAGGGGCCG GTCTGGGCCT GGGCAACTGG 
AACAACAATG CAGGCATCCC TGGGTCCTCA GAGGACCTAT CAACTGAGTT TGGTCACCAC 
ATCCACCGGG GATATCAAGG TGAGAAGGAC AGAGGCCACA GAGAAGAGGG TGAAGACTTC 
TCCAGGGAAT ATGGCCACAG GGTCCAAGAC CACAGGTACC CTGGCCGCGA GGTTGGAGAG 
GAGAATGTCT CTGAAGAGGT CTTCAGAGGG CATGTTAGAC AGCTCCACGG GCACCGGGAA 
CATGACAATG AAGATTTAGG AGACTCGGCA GAGAACCACC TCCCCAGACA GAGGAGCCAC 
AGCCACGAAG ATGAGGATGG CATTGTCTCC AGTGAGTATC ACCGTCACGT CCCCAGGCAT 
GCCCACCATG GCCACGGAGA GGAAGATGAT GACGATGATG GAGGAGAGGA GGAGGAGAGG 
GTGGATGTGA TGGAGGACTC TGATGATAAT GAACACCAGG TCCATGGTCA CCAGAGCCAC 
TCAAAGGAGA GAGATGAACT CCATCATGCC CACAGCCACA GGCACCAAGG CCACAGTGAT 
GATGACGATG ACGATGGTGT CTCTACTGAG CATGGACACC AAGCTCACAG ATATCAGGAT 
CATGAGGAGG AAGACGATGG GGACTCAGAT GAAGACAGTC ACACCCACAG AGTTCAAGGC 
CGAGAAGATG AAAATGATGA TGAAGACGGT GACTCTGGTG AATACAGACA CCATACCCAG 
GACCACCAAG GCCACAACGA AGAGCAAGAT GACGATGATG ATGATGATGA TGATGATGAA 
GATAAAGAAG ACTCCACTGA GCACCGGCAC CAGACCCAAG GCCACAGGAA GGAAGAAGAT 
GAGGATGAGT CAGATGAAGA TGATCATCAT GTCTCCAGGC ATGGACGCCA AGGCTATGAA 
GAAGAAGAAG ATGATGATGA TGATGATGGA GATGATGACT CTACTGAGCA TGTGCATCAA 
GCCCACAGAC ACAGAGACCA TGAGCACAAA GATGATGAGG ATGACTCAGA AGAAGACTAC 
CATCATGTCC CCAGCCATGG CCGCCAAAGC CACCAAAATG AGGAAGAGGA AGATGAGGCT 
GTATCCACTG AACACTGGCA CCAGTCTCCT AGACATGCTC ACCATGATCT TGGACGTGAG 
AGTGAAGAAG AGGTAGCAGT CAAGTACAGC CACCATGTTG CAAGCCACCG TCCCCAAGGC 
CACAATGCTG ACAGGGAGGA GGACTCTCTA GAAGAACACA TGAATGAAGT CCCAGGCCAT 
CACCACCACA GAGCCTCCAG GGGTGATGAT GAGGACATTT CTACTGAGTT TGGCCACAAG 
GCCCCCAGCC ACAGGCTACA AGATCAAGAT GAAAGGGCGA GGCAGGGTCA CAGAGAGCCT 
GTTCAGGGAG AGATTGCTCA TCAGCCCCTG CAACCCACAG GACCCAGTTC AAGAGAATCA 
AGGAAGGAAG GTGACCACAG CTCTCAAGAG GGAGATGAAG ACCCAGAGCA GAGGCAAGCC 
CATAGTGAGG AGGAGAAGGA GGAGGAGGAG GAGGAGGAGG AGGAGGAGGA GGAGGAGAAA 
GAGGGGGGCC ATAGCCTCCC CATGAGCCAG GAAGATGATG AAGAGGAAGA AAAAGATGAG 
AAAGAAAGCA AGGTAGACAG GGCTGCAGTT TCAGCTCCAC TGAGCCATCA TAGGAAGCAG 
GGGGAGGAAG AGGAGGAGGA AGAGGAGGAG GAAGAGGAGG AGATCCTGGA GGAAAACCTA 
CTACCTTTCA CCATTATCCC AAACCCACTC GCTGGGAGAG AGGTGGCCAG AGAAGGTTCC 
AGTGAAGAGG AGAGCCGTGA GGTCACAGGT CAGCAGGATG CCCAGGAGTA CGAAAATTAC 
CAGCCAGGGT CTTTGTGTGG CTACTGTTCT TTCTGCAACC GATGTACCGA ATGTGAAAGC 
TGTCACTGTG ATGAGGAGAA CATGGGGGAA CACTGTGACC AGTGTCAGCA CTGTCAATTC 
TGCTACCTCT GTCCGCTGGT GTGTGACACG CTCTGCACTC CAGGAAGCTA CGTTGACTAT 
TTCTCCTCCT CTCTGTATCA AGCCCTGGCT GACATGTTGG AGACTCCAGA GCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant.
Cardiovascular research113(11)1403-1417(2017 Sep)
Tzimas C,Johnson DM,Santiago DJ,Vafiadaki E,Arvanitis DA,Davos CH,Varela A,Athanasiadis NC,Dimitriou C,Katsimpoulas M,Sonntag S,Kryzhanovska M,Shmerling D,Lehnart SE,Sipido KR,Kranias EG,Sanoudou D

Characterization of Ca(2+)-Dependent Protein-Protein Interactions within the Ca(2+) Release Units of Cardiac Sarcoplasmic Reticulum.
Molecules and cells39(2)149-55(2016 02)
Rani S,Park CS,Sreenivasaiah PK,Kim DH

Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT.
Cardiovascular research108(2)299-311(2015 11)
Liu B,Ho HT,Brunello L,Unudurthi SD,Lou Q,Belevych AE,Qian L,Kim DH,Cho C,Janssen PM,Hund TJ,Knollmann BC,Kranias EG,Györke S

Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress.
Basic research in cardiology108(3)344(2013 May)
Park CS,Chen S,Lee H,Cha H,Oh JG,Hong S,Han P,Ginsburg KS,Jin S,Park I,Singh VP,Wang HS,Franzini-Armstrong C,Park WJ,Bers DM,Kranias EG,Cho C,Kim DH

Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase.
American journal of physiology. Heart and circulatory physiology293(3)H1581-9(2007 Sep)
Arvanitis DA,Vafiadaki E,Fan GC,Mitton BA,Gregory KN,Del Monte F,Kontrogianni-Konstantopoulos A,Sanoudou D,Kranias EG

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Hrc cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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