Atf6b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Atf6b
Entrez Gene ID	12915
Full Name	activating transcription factor 6 beta
Synonyms	AA617266,ATF6beta,Creb-rp,Crebl1
General protein information	Preferred Names activating transcription factor 6 beta Names cyclic AMP-dependent transcription factor ATF-6 beta ATF6-beta cAMP response element binding protein-related protein cAMP-dependent transcription factor ATF-6 beta cAMP-responsive element-binding protein-like 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 B1\|17 18.22 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_017406.4	NP_059102.2	cyclic AMP-dependent transcription factor ATF-6 beta

Pathways from BioSystems

Homologies

Homo sapiens (human)	ATF6B	NP_004372.3
Danio rerio (zebrafish)	atf6b	NP_001071188.1
Pan troglodytes (chimpanzee)	ATF6B	XP_001151201.2
Macaca mulatta (Rhesus monkey)	ATF6B	XP_002803728.1
Rattus norvegicus (Norway rat)	Atf6b	NP_001002809.2
Xenopus tropicalis (tropical clawed frog)	atf6b	XP_002941309.2
Canis lupus familiaris (dog)	ATF6B	XP_005627806.1
Bos taurus (cattle)	ATF6B	NP_001077152.1
Mus musculus (house mouse)	Atf6b	NP_059102.2

Gene Ontology
Bibliography

Related articles in PubMed

Overlapping and differential functions of ATF6α versus ATF6β in the mouse heart.
Correll RN, Grimes KM, Prasad V, Lynch JM, Khalil H, Molkentin JD
Scientific reports9(1)2059(2019 Feb)

Paradoxical roles of ATF6α and ATF6β in modulating disease severity caused by mutations in collagen X.
Forouhan M, Mori K, Boot-Handford RP
Matrix biology : journal of the International Society for Matrix Biology7050-71(2018 09)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bućan M, Murray SA
Nature537(7621)508-514(2016 09)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Atf6b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atf6b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17068	NM_017406.4 Latest version!	Mus musculus activating transcription factor 6 beta (Atf6b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Atf6b ( NM_017406.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_059102.2 Mus musculus activating transcription factor 6 beta (Atf6b), mRNA.

Price & Availability↑

CloneID	OMu17068
Clone ID Related Accession (Same CDS sequence)	NM_017406.4
Accession Version	NM_017406.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2121bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573747200000
Organism	Mus musculus(house mouse)
Product	cyclic AMP-dependent transcription factor ATF-6 beta
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CT009767.6, AK146671.1 and BP766726.1. On Nov 6, 2012 this sequence version replaced NM_017406.3. Sequence Note: An in-frame AUG is located 15 codons upstream of the annotated translation start site but is not being annotated as a start site since it is in a weak Kozak sequence context and very near the 5' end of the transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013534.1, AK146671.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGGGGG GTGGGGGGAA GATGGCGGAG CTGATGCTCC TCAGTGAGAT CGCCGACCCG 
ACGCGCTTCT TCACCGACAA CCTGCTGAGT CCGGAGGACT GGGACAGCAC CTTGTACAGT 
GGCCTGGATG AAGTGGCCGA GGAGCAGGCA CAGTTGTTCC GTTGCGTGGA GCAGGATGTC 
CCGTTTGACA GCAGCTCTCT GGATGTGGGG ATGGATGTCA GCCCCCCTGA GCCCCCTTGG 
GACCCTCTAC CCATCTTCCC AGATCTTCAG GTGAAGTCCG AGCCATCCTC TCCCTGCTCG 
TCCTCCTCCC TCAGCTCAGA GTCCTCACAT CTTTCCACAG AGCCCCCCAG CCAGGTCCCT 
GGTGTAGGCG AGGTGCTGCA TGTGAAGATG GAGTCCCTGG CACCCCCACT CTGCCTGCTG 
GGGGATGATC CAGCATCCCC CTTTGAAACG GTCCAGATCA CTGTGGGCTC TGCCTCTGAT 
GATCTTTCAG ATATCCAGAC CAAGCTGGAA CCTGCCTCTC CGTCTTCTTC TGTCCACTCT 
GAGGCCTCCT TGCTGTCAGC AGACTCTCCC AGTCAGCCTT TTATAGGAGA GGAGGTTCTG 
GAAGTGAAGA CAGAGTCTCC GTCCCCTCCA GGGTGCCTCC TGTGGGATGT CCCAGCCTCT 
TCGCTCGGAG CTGTCCAGAT CAGCATGGGT CCATCCCCTG ATAGTTCCTC AGGGAAAGCT 
CCGGCCACTC GGAAGCCTCC ACTGCAGCCC AAGCCTGTGG TACTAACCAC AGTTCCGGTG 
CCACCTAGAG CTGGGCCTAC CAGCGCTGCC GTCCTCCTGC AACCCCTGGT CCAGCAGCCT 
GCGGTGTCCC CAGTGGTCCT CATCCAAGGT GCTATCCGAG TCCAGCCTGA AGGGCCAGCT 
CCCGCAGCTC CCCGGCCTGA GAGGAAGAGC ATTGTTCCAG CCCCTATGCC GGGGAACTCC 
TGCCCGCCTG AAGTGGATGC AAAGCTGTTG AAGCGGCAGC AGCGGATGAT CAAGAATCGA 
GAGTCGGCCT GCCAGTCCCG CCGCAAGAAG AAAGAGTACC TGCAAGGCCT GGAGGCCCGG 
CTGCAGGCTG TGCTGGCCGA CAACCAGCAG CTGCGCAGGG AGAACGCTGC CCTCCGGCGG 
CGGCTGGAGG CCCTGCTGGC AGAGAACAGC GGGCTCAAGC TGGGGTCTGG AAACAGGAAG 
GTTGTCTGCA TCATGGTCTT CCTTCTCTTC ATTGCCTTCA ACTTTGGGCC TGTGAGCATC 
AGCGAGCCGC CTCCAGCTCC CATGTCTCCT CGGATGAGCA GGGAGGAACC TCGACCCCAG 
AGGCACCTGC TGGGCTTCTC AGAACCAGGG CCAGCTCATG GCATGGAACC CCTTCGGGAA 
GCCGCCCAGA GCCCCGGGGA GCAGCAGCCC AGCTCTGCAG GCAGGCCCAG CTTCAGAAAC 
CTGACGGCCT TCCCCGGGGG AGCCAAGGAG CTGCTGCTGA GAGACCTGGA CCAGCTCTTC 
CTCTCCTCAG ACTGTCGCCA TTTCAACCGA ACTGAGTCTC TGAGGCTTGC TGATGAGCTG 
AGTGGCTGGG TCCAACGTCA CCAGAGAGGT CGACGGAAGA TACCTCACAG GGCCCAGGAG 
AGACAGAAGT CTCAGCTACG GAAGAAGTCT CCTCCAGTGA AACCTGTCCC CACCCAACCT 
CCAGGACCCC CTGAAAGGGA CCCCGTGGGC CAGCTGCAGC TCTACCGCCA CCCCGGCCGC 
TCGCAGCCGG AGTTTCTAGA CGCAATTGAC CGGAGGGAGG ATACCTTCTA TGTTGTCTCC 
TTCCGAAGGG ACCACCTGCT GCTCCCAGCC ATCAGCCACA ACAAGACATC CAGGCCCAAG 
ATGTCGCTGG TGATGCCAGC CATGGCCCCC AATGAGACCG TGTCAGGCCG GGGCCCCCCA 
GGGGACTATG AGGAGATGAT GCAGATCGAG TGTGAGGTCA TGGACACCAG GGTGATTCAC 
ATCAAGACCT CTACGGTGCC CCCCTCGCTC CGGAAGCAGC CGTCCCCATC CCCGGGCAAT 
ACCACAGGTG GCCCCTTGCC AGGCTCCGCA GCTAGTCCTG CCCATCAGGC CTCCCAGCCC 
CTCTACCTCA ATCACCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059102.2
CDS	69..2189
Translation	MVGGGGKMAELMLLSEIADPTRFFTDNLLSPEDWDSTLYSGLDEVAEEQAQLFRCVEQDVPFDSSSLDVGMDVSPPEPPWDPLPIFPDLQVKSEPSSPCSSSSLSSESSHLSTEPPSQVPGVGEVLHVKMESLAPPLCLLGDDPASPFETVQITVGSASDDLSDIQTKLEPASPSSSVHSEASLLSADSPSQPFIGEEVLEVKTESPSPPGCLLWDVPASSLGAVQISMGPSPDSSSGKAPATRKPPLQPKPVVLTTVPVPPRAGPTSAAVLLQPLVQQPAVSPVVLIQGAIRVQPEGPAPAAPRPERKSIVPAPMPGNSCPPEVDAKLLKRQQRMIKNRESACQSRRKKKEYLQGLEARLQAVLADNQQLRRENAALRRRLEALLAENSGLKLGSGNRKVVCIMVFLLFIAFNFGPVSISEPPPAPMSPRMSREEPRPQRHLLGFSEPGPAHGMEPLREAAQSPGEQQPSSAGRPSFRNLTAFPGGAKELLLRDLDQLFLSSDCRHFNRTESLRLADELSGWVQRHQRGRRKIPHRAQERQKSQLRKKSPPVKPVPTQPPGPPERDPVGQLQLYRHPGRSQPEFLDAIDRREDTFYVVSFRRDHLLLPAISHNKTSRPKMSLVMPAMAPNETVSGRGPPGDYEEMMQIECEVMDTRVIHIKTSTVPPSLRKQPSPSPGNTTGGPLPGSAASPAHQASQPLYLNHP

Target ORF information:

RefSeq Version	NM_017406.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus activating transcription factor 6 beta (Atf6b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017406.4

ORF Insert Sequence:

ATGGTGGGGG GTGGGGGGAA GATGGCGGAG CTGATGCTCC TCAGTGAGAT CGCCGACCCG 
ACGCGCTTCT TCACCGACAA CCTGCTGAGT CCGGAGGACT GGGACAGCAC CTTGTACAGT 
GGCCTGGATG AAGTGGCCGA GGAGCAGGCA CAGTTGTTCC GTTGCGTGGA GCAGGATGTC 
CCGTTTGACA GCAGCTCTCT GGATGTGGGG ATGGATGTCA GCCCCCCTGA GCCCCCTTGG 
GACCCTCTAC CCATCTTCCC AGATCTTCAG GTGAAGTCCG AGCCATCCTC TCCCTGCTCG 
TCCTCCTCCC TCAGCTCAGA GTCCTCACAT CTTTCCACAG AGCCCCCCAG CCAGGTCCCT 
GGTGTAGGCG AGGTGCTGCA TGTGAAGATG GAGTCCCTGG CACCCCCACT CTGCCTGCTG 
GGGGATGATC CAGCATCCCC CTTTGAAACG GTCCAGATCA CTGTGGGCTC TGCCTCTGAT 
GATCTTTCAG ATATCCAGAC CAAGCTGGAA CCTGCCTCTC CGTCTTCTTC TGTCCACTCT 
GAGGCCTCCT TGCTGTCAGC AGACTCTCCC AGTCAGCCTT TTATAGGAGA GGAGGTTCTG 
GAAGTGAAGA CAGAGTCTCC GTCCCCTCCA GGGTGCCTCC TGTGGGATGT CCCAGCCTCT 
TCGCTCGGAG CTGTCCAGAT CAGCATGGGT CCATCCCCTG ATAGTTCCTC AGGGAAAGCT 
CCGGCCACTC GGAAGCCTCC ACTGCAGCCC AAGCCTGTGG TACTAACCAC AGTTCCGGTG 
CCACCTAGAG CTGGGCCTAC CAGCGCTGCC GTCCTCCTGC AACCCCTGGT CCAGCAGCCT 
GCGGTGTCCC CAGTGGTCCT CATCCAAGGT GCTATCCGAG TCCAGCCTGA AGGGCCAGCT 
CCCGCAGCTC CCCGGCCTGA GAGGAAGAGC ATTGTTCCAG CCCCTATGCC GGGGAACTCC 
TGCCCGCCTG AAGTGGATGC AAAGCTGTTG AAGCGGCAGC AGCGGATGAT CAAGAATCGA 
GAGTCGGCCT GCCAGTCCCG CCGCAAGAAG AAAGAGTACC TGCAAGGCCT GGAGGCCCGG 
CTGCAGGCTG TGCTGGCCGA CAACCAGCAG CTGCGCAGGG AGAACGCTGC CCTCCGGCGG 
CGGCTGGAGG CCCTGCTGGC AGAGAACAGC GGGCTCAAGC TGGGGTCTGG AAACAGGAAG 
GTTGTCTGCA TCATGGTCTT CCTTCTCTTC ATTGCCTTCA ACTTTGGGCC TGTGAGCATC 
AGCGAGCCGC CTCCAGCTCC CATGTCTCCT CGGATGAGCA GGGAGGAACC TCGACCCCAG 
AGGCACCTGC TGGGCTTCTC AGAACCAGGG CCAGCTCATG GCATGGAACC CCTTCGGGAA 
GCCGCCCAGA GCCCCGGGGA GCAGCAGCCC AGCTCTGCAG GCAGGCCCAG CTTCAGAAAC 
CTGACGGCCT TCCCCGGGGG AGCCAAGGAG CTGCTGCTGA GAGACCTGGA CCAGCTCTTC 
CTCTCCTCAG ACTGTCGCCA TTTCAACCGA ACTGAGTCTC TGAGGCTTGC TGATGAGCTG 
AGTGGCTGGG TCCAACGTCA CCAGAGAGGT CGACGGAAGA TACCTCACAG GGCCCAGGAG 
AGACAGAAGT CTCAGCTACG GAAGAAGTCT CCTCCAGTGA AACCTGTCCC CACCCAACCT 
CCAGGACCCC CTGAAAGGGA CCCCGTGGGC CAGCTGCAGC TCTACCGCCA CCCCGGCCGC 
TCGCAGCCGG AGTTTCTAGA CGCAATTGAC CGGAGGGAGG ATACCTTCTA TGTTGTCTCC 
TTCCGAAGGG ACCACCTGCT GCTCCCAGCC ATCAGCCACA ACAAGACATC CAGGCCCAAG 
ATGTCGCTGG TGATGCCAGC CATGGCCCCC AATGAGACCG TGTCAGGCCG GGGCCCCCCA 
GGGGACTATG AGGAGATGAT GCAGATCGAG TGTGAGGTCA TGGACACCAG GGTGATTCAC 
ATCAAGACCT CTACGGTGCC CCCCTCGCTC CGGAAGCAGC CGTCCCCATC CCCGGGCAAT 
ACCACAGGTG GCCCCTTGCC AGGCTCCGCA GCTAGTCCTG CCCATCAGGC CTCCCAGCCC 
CTCTACCTCA ATCACCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Overlapping and differential functions of ATF6α versus ATF6β in the mouse heart.
Scientific reports9(1)2059(2019 Feb)
Correll RN,Grimes KM,Prasad V,Lynch JM,Khalil H,Molkentin JD

Paradoxical roles of ATF6α and ATF6β in modulating disease severity caused by mutations in collagen X.
Matrix biology : journal of the International Society for Matrix Biology7050-71(2018 09)
Forouhan M,Mori K,Boot-Handford RP

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bućan M,Murray SA

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

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Atf6b cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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