Gene Symbol | HEXB |
Entrez Gene ID | 493928 |
Full Name | hexosaminidase subunit beta |
Gene Type | protein-coding |
Organism | Felis catus(domestic cat) |
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ORF » Species Summary » Felis catus » HEXB cDNA ORF clone
Gene Symbol | HEXB |
Entrez Gene ID | 493928 |
Full Name | hexosaminidase subunit beta |
Gene Type | protein-coding |
Organism | Felis catus(domestic cat) |
mRNA | Protein | Name |
---|---|---|
NM_001009333.2 | NP_001009333.2 | beta-hexosaminidase subunit beta |
XM_023238898.1 | XP_023094666.1 | beta-hexosaminidase subunit beta isoform X1 |
AAV-mediated gene delivery attenuates neuroinflammation in feline Sandhoff disease.
Bradbury AM, Peterson TA, Gross AL, Wells SZ, McCurdy VJ, Wolfe KG, Dennis JC, Brunson BL, Gray-Edwards H, Randle AN, Johnson AK, Morrison EE, Cox NR, Baker HJ, Sena-Esteves M, Martin DR
Neuroscience340117-125(2017 01)
Neurodegenerative lysosomal storage disease in European Burmese cats with hexosaminidase beta-subunit deficiency.
Bradbury AM, Morrison NE, Hwang M, Cox NR, Baker HJ, Martin DR
Molecular genetics and metabolism97(1)53-9(2009 May)
Nonsense mutation of feline beta-hexosaminidase beta-subunit (HEXB) gene causing Sandhoff disease in a family of Japanese domestic cats.
Kanae Y, Endoh D, Yamato O, Hayashi D, Matsunaga S, Ogawa H, Maede Y, Hayashi M
Research in veterinary science82(1)54-60(2007 Feb)
An inversion of 25 base pairs causes feline GM2 gangliosidosis variant.
Martin DR, Krum BK, Varadarajan GS, Hathcock TL, Smith BF, Baker HJ
Experimental neurology187(1)30-7(2004 May)
Characterization of the molecular defect in a feline model for type II GM2-gangliosidosis (Sandhoff disease).
Muldoon LL, Neuwelt EA, Pagel MA, Weiss DL
The American journal of pathology144(5)1109-18(1994 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following HEXB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HEXB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OFb24634 | |
Clone ID Related Accession (Same CDS sequence) | NM_001009333.2 | |
Accession Version | NM_001009333.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1500bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 1544198400000 | |
Organism | Felis catus(domestic cat) | |
Product | beta-hexosaminidase subunit beta | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from S70340.1. On Aug 16, 2008 this sequence version replaced NM_001009333.1. ##Evidence-Data-START## Transcript exon combination :: S70340.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01761015, SAMN01831871 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCCGCTCT CGGTGAAGAC GTCTCCGCGC CTGCTGCACC TCTCCCGCGA CAACTTCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001009333.2 |
CDS | 113..1612 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCGCTCT CGGTGAAGAC GTCTCCGCGC CTGCTGCACC TCTCCCGCGA CAACTTCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OFb69813 | |
Clone ID Related Accession (Same CDS sequence) | XM_023238898.1 | |
Accession Version | XM_023238898.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2190bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 1512921600000 | |
Organism | Felis catus(domestic cat) | |
Product | beta-hexosaminidase subunit beta isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_018723.3) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Felis catus Annotation Release 104 Annotation Version :: 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 22% of CDS bases ##RefSeq-Attributes-END## |
1 | ATGCCTCTTC GCAAGAACTT GGGCCTTCGT GGAGGCGTGG ACCCCTCCCA CTGTGGACCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_023094666.1 |
CDS | 1..2190 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCTCTTC GCAAGAACTT GGGCCTTCGT GGAGGCGTGG ACCCCTCCCA CTGTGGACCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
AAV-mediated gene delivery attenuates neuroinflammation in feline Sandhoff disease. |
Neurodegenerative lysosomal storage disease in European Burmese cats with hexosaminidase beta-subunit deficiency. |
Nonsense mutation of feline beta-hexosaminidase beta-subunit (HEXB) gene causing Sandhoff disease in a family of Japanese domestic cats. |
An inversion of 25 base pairs causes feline GM2 gangliosidosis variant. |
Characterization of the molecular defect in a feline model for type II GM2-gangliosidosis (Sandhoff disease). |