CRISPR News

Explore advancements in NK cell engineering for cancer therapies from Dr. Rezvani’s lab as presented at AACR.

Traditional autologous CAR-T therapies, which rely on patient-derived T cells, face significant limitations, including lengthy manufacturing times, high costs, and variability in cell quality, particularly for patients with

Theory to action: Applying CRISPR in Research

As presented at ASGCT 2023 several innovative approaches leveraging antibody-conjugated AAVs, shuttle peptides, and viral-like particles are making possible the targeted delivery of gene and editing cargo in vivo.

The success of cancer immunotherapies, such as CAR T cells for targeting tumor cells in hematological malignancies, has spurred an unprecedented push to develop more and improved living drugs.

Learn how CRISPR screens, such as knock-out, knock-in, CRISPRa, and CRISPRi, are helping to identify molecular factors and programs critical for developing effective cell therapies.

Learn how a new T cell receptor, HIT, engineered by Dr. Michel Sadelain’s group achieves greater sensitivity for tumor antigens than CARs.

Learn how CRISPR/Cas9 editing tools support precise mlo gene editing to develop plant varieties resistant to common fungal diseases such as powdery mildew while retaining growth potential and productivity.

CRISPR/Cas9 enables targeted genomic insertions, clearing the way for precise therapies for cancer, rare diseases, and more.

Learn how CRISPR/Cas9 editing tools have been leveraged to target the SOD1 gene in a mouse model of ALS, preventing the development of ALS pathology.