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thermogenesis model

A theory of the origin of life, particularly of how prebiotic structures utilized environmental energy to drive synthetic processes. Basing itself on the current belief that the most primitive organisms are the thermophilic micro-organisms, the theory holds that prebiotic synthesis was driven by temperature variation, perhaps owing to convection currents near undersea thermal vents. A population of proteins is assumed, having been formed by processes postulated by other theories of the origin of life. Among these proteins was the original enzyme, an ATP synthase, which underwent a reversible temperature-dependent folding/unfolding: cycles of temperature variation drove the synthesis of ATP, or other phosphoanhydride, by binding substrates at a lower temperature and facilitating synthesis of an anhydride bond on the protein surface; as the protein unfolded at the higher temperature, it dissociated the ATP (protein-associated thermosynthesis). When the components of membranes became available, the synthase activity was incorporated into them and formed primitive chemosmotic vesicles (membrane-associated thermosynthesis). Variations in incident light e.g. under the waves of shallow water, might have energized primitive photosynthetic vesicles.Muller, W.J. (1996) Essays Biochem. 31, 103-119

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