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kinetic partitioning

kinetic partitioning The hypothesis that in folding of a newly synthesized or renaturing biopolymer, a protein or RNA quickly collapses into condensed structures characterized by a high degree of secondary structure. One of these may be the native conformation (the others are “kinetic traps”), but significant energy barriers isolate these forms. kinetic partitioning is the hypothetical basis of recognition of proteins by molecular chaperones: quickly after synthesis, a cytosolic protein achieves its native conformation and thus avoids binding to the chaperone, while other proteins, e.g. those with leader sequences, much more slowly fold into native structures, which affords the chaperone the opportunity to bind them.(see funnel concept; paradox of Levinthal)Hardy, S.J.S. and Randall, L.L. (1991) Science 251, 439-443; Thirumalai, D. and Woodson, S.A. (1996) Accts. Chem. Res. 29, 433-439; Treiber, D.K. and Williamson, J.R. (1999) Curr. Opin. Struct. Biol. 9, 339-345

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