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FGL1 Fc Chimera, Human

Immobilized h_LAG3 at 5 μg/ml (100 μl/well) can bind FGL1 Fc Chimera, Human with a linear range of 0.097–50 μg/ml when detected by Mouse Anti-Human IgG Fc-HRP. Background was subtracted from data points before curve fitting.

FGL1 Fc Chimera, Human

FGL1 (Fibrinogen-like protein 1), also known as hepatocyte-derived fibrinogen-related protein 1 (HFREP-1), HP-041, hepassocin (HPS), and liver fibrinogen-related protein 1 (LFIRE-1), is a liver-specific secreted protein belonging to the fibrinogen superfamily whose members share a fibrinogen domain at their C-termini. FGL1 is an immune suppressive molecule that inhibits the activation of antigen-specific T cells by acting as a major ligand of LAG3, and binds LAG3 independently of MHC class II.
Z03567
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Product Introduction
Species Human
Protein Construction
FGL1 (Leu23-Ile312)
Accession # Q08830		 hFc
N-term C-term
Purity > 95% as analyzed by SDS-PAGE
Endotoxin Level < 1 EU/μg of protein by gel clotting method
Biological Activity Immobilized h_LAG3 at 5.0 μg/ml (100 μl/well) can bind FGL1, hFc, Human with a linear range of 0.097–50 μg/ml when detected by Mouse Anti-Human IgG Fc-HRP.
Expression System HEK 293
Apparent Molecular Weight ~61.8 kDa, on SDS-PAGE under reducing conditions.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

Examples
  • FGL1 Fc Chimera, Human
    • FGL1 Fc Chimera, Human

    Immobilized h_LAG3 at 5 μg/ml (100 μl/well) can bind FGL1 Fc Chimera, Human with a linear range of 0.097–50 μg/ml when detected by Mouse Anti-Human IgG Fc-HRP. Background was subtracted from data points before curve fitting.


Background
Target Background FGL1 (Fibrinogen-like protein 1), also known as hepatocyte-derived fibrinogen-related protein 1 (HFREP-1), HP-041, hepassocin (HPS), and liver fibrinogen-related protein 1 (LFIRE-1), is a liver-specific secreted protein belonging to the fibrinogen superfamily whose members share a fibrinogen domain at their C-termini. FGL1 is an immune suppressive molecule that inhibits the activation of antigen-specific T cells by acting as a major ligand of LAG3, and binds LAG3 independently of MHC class II.
Synonyms HFREP-1; HP-041; HPS; LFIRE-1

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.