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CD38, Human

CD38, Human at 1 μg/ml (100 μl/well) can bind Human CD38 Antibody (38.F2), Mouse with EC50=1.640 ng/ml when detected by M6 Goat Anti Mouse (Fc). Background was subtracted from data points before curve fitting.

CD38, Human

Recombinant Human CD38 produced in HEK 293 cells is a polypeptide chain containing 258 amino acids. A fully biologically active molecule, rhCD38 has a molecular mass of 35.7 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Z03394
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Product Introduction
Species Human
Protein Construction
CD38 (Val43-lle300)
Accession # P28907
Purity > 95% as analyzed by SDS-PAGE
Endotoxin Level < 1 EU/μg of protein by gel clotting method
Biological Activity Immobilized CD38, Human at 1.0 μg/ml (100 μl/well) can bind Human CD38 Antibody (38.F2), Mouse with EC50=1.640 ng/ml when detected by M6 Goat Anti Mouse (Fc).
Expression System HEK 293
Apparent Molecular Weight ~35.7 kDa, on SDS-PAGE under reducing conditions.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

Examples
  • CD38, Human
    • CD38, Human

    CD38, Human at 1 μg/ml (100 μl/well) can bind Human CD38 Antibody (38.F2), Mouse with EC50=1.640 ng/ml when detected by M6 Goat Anti Mouse (Fc). Background was subtracted from data points before curve fitting.


Background
Target Background CD38 (also referred to as T10 antigen) is a nonlineage-restricted type II transmembrane glycoprotein that has emerged as an intracellular calcium ion mobilizing messenger. It can serve as an ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose. The enzymatic functions of CD38 probably contribute to an array of its immunoregulatory functions. It has been found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. Soluble CD38 and the ability of membrane-bound CD38 to become internalized in response to appropriate stimuli suggest that extracellular and intracellular roles for this protein are equally plausible.
Synonyms CD38; Cluster of Differentiation 38

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.