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MEC/CCL28, Rat

Mucosae-associated Epithelial Chemokine (MEC)/CCL28 (CC chemokine ligand 28) is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T-cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines.
Z02961
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Product Introduction
Species Rat
Protein Construction
CCL28 (Ser20-Arg135)
Accession # Q91Y39
Purity > 96% as analyzed by SDS-PAGE
> 96% as analyzed by HPLC
Endotoxin Level < 1 EU/μg of protein by LAL method
Biological Activity Fully biologically active when compared to standard. The biologically active determined by a chemotaxis bioassay using human lymphocytes is in a concentration range of 5.0-50.0 ng/ml.
Expression System E. coli
Theoretical Molecular Weight 13.1 kDa
Formulation Lyophilized from a 0.2 μm filtered solution in 20 mM PB, pH 7.4, 200 mM NaCl.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles.

Background
Target Background Mucosae-associated Epithelial Chemokine (MEC)/CCL28 (CC chemokine ligand 28) is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T-cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines.
Synonyms Chemokine (C-C motif) ligand 28; CCL-28; SCYA28; MGC71902; Small-inducible cytokine A28; Mucosae-associated epithelial chemokine; Protein CCK1

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.