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| Z02811 | |
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| $165.00 | |
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| Ask us a question | |
| Species | Gila monster | |
| Protein Construction |
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| Purity |
> 96% as analyzed by SDS-PAGE > 96% as analyzed by HPLC |
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| Endotoxin Level | < 0.2 EU/μg of protein by LAL method | |
| Expression System | E. coli | |
| Theoretical Molecular Weight | 4.2 kDa | |
| Application |
1. Regulates Glucose levels rapidly. 2. Reduces Insulin resistence. 3. Reduces Glucagon. 4. Reduces HbA1c. 5. Stimulates beta cell growth which stimulates insulin production. |
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| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4. | |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. | |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
| Target Background | Exendin-4 is a novel 39-amino acid peptide isolated from the venom of the Gila monster Heloderma suspectum. It shares 53% sequence homology with GLP-17-36amide and interacts with the same membrane receptor. Exendin-4 enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying in vivo. It also promotes ß-cell proliferation and neogenesis in vitro and in animal models. |
| Synonyms | Exendin-4 |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
