PEGS BOSTON 2025

Luncheon Presentation:

Time: Tuesday, May 13, 2025, 12:50 PM - 1:20 PM EST (30 Minutes)

Track: Difficult-to-Express Proteins

Speaker: Dr. Darren Yuan

Job Title: Director of Production Support Department, GenScript

Bio: Dr. Darren X. Yuan is the Director of Production Support of Protein Department at GenScript with extensive experience in recombinant protein and antibody production. He specializes in developing high-throughput, high-yield and high-purity protein expression and purification solutions for early-stage protein drug development, and provides expert guidance to protein production teams. Darren led the establishment of GenScript’s TurboCHO™ Platform, significantly advancing protein production capabilities to meet industrial and academic standards.

Presentation Title: Next-Gen Bi-specific Antibody Manufacturing: Achieving Superior Productivity and Purity with TurboCHO™

Abstract:Bispecific antibodies (BsAbs), pivotal in next-gen antibody therapies, face complex production challenges including secretion issues, chain imbalance, and impurity formation. GenScript’s TurboCHO technology addresses these with a streamlined workflow—optimizing cell lines, vectors, and media through iterative DOE-driven cycles, and refining chain ratios for enhanced yields. A tailored purification roadmap, powered by various chromatography selection, ensures high purity by leveraging molecular differences among impurities. Real-world cases demonstrate this systematic approach effectively resolves common BsAb production hurdles, supporting diverse formats from concept to clinic.

Luncheon Presentation:

Time: Wednesday, May 14, 2025, 12:00 PM - 12:30 PM EST (30 Minutes)

Track: Optimizing Protein Expression

Speaker: Dr. Luciana Rosselli-Murai

Job Title: Head of Field Application Scientist

Company: GenScript USA Inc

Bio: Dr. Luciana K. Rosselli-Murai is a highly skilled research scientist with over 7 years of experience in cell biology, cancer research, and cell signaling pathways. As the Head of the Field Application Scientist team for GenScript’s Products and Instruments Division, she oversees scientific operations across the USA and Europe. Dr. Rosselli-Murai holds a PhD in Genetics and Molecular Biology from Universidade Estadual de Campinas and completed her postdoctoral research at the University of Michigan. She specializes in GPCR research, protein biochemistry, and advanced imaging techniques, with a strong passion for driving innovation in Life Sciences and biological research.

Title: Improving Throughput and Consistency in Plasmid Purification: A Novel Approach

Abstract:

Plasmid DNA purification is a critical step in various applications, including gene therapy, vaccine development, and synthetic biology. Traditional methods often struggle with scalability and consistency. This presentation explores the AmMag™ Quatro Mini and Maxi systems, which integrate automation and magnetic bead technology for high-throughput, mini- and maxi-scale purification. These systems reduce hands-on time, increase efficiency, and ensure reproducibility, offering scalable solutions for high-quality plasmid production.

30min Presentation:

Time: Friday, May 16, 2025, 10:00 AM - 10:30 AM EST (30 Minutes)

Track: Engineering Bispecific and Multifunctional Antibodies

Speaker: Amanda Grimm

Job Title: Sr. Segment Marketing Manager

Company: GenScript USA Inc

Bio:

Amanda Grimm is a seasoned life sciences professional with a diverse background spanning immunopathology research, immunoassay development, manufacturing, and commercialization. Since joining GenScript in 2021, she has led strategic marketing initiatives for the company’s antibody drug discovery portfolio, helping researchers accelerate their therapeutic development.

Before transitioning into marketing, Amanda worked extensively in immunopathology research, focusing on animal diseases and the development of immunoassays for both research and commercial applications. Her expertise extends to product management of automation technologies and diagnostics, giving her a well-rounded perspective on the scientific and business aspects of biopharma innovation.

At GenScript, Amanda drives portfolio education and global marketing campaigns to support researchers in navigating the complexities of antibody drug development. She is passionate about translating cutting-edge technologies into impactful solutions that empower scientists to bring novel therapeutics to market.

Amanda holds dual Bachelor of Science degrees in Microbiology and Biochemistry, as well as a Professional Science Master’s (PSM) from Washington State University.

Title: Navigating the Complexity: GenScript’s End-to-End Solutions for Bispecific Antibody Discovery

Abstract: Bispecific antibody drug development is a complex process requiring careful consideration of target biology, mechanism of action, antibody format, and other critical factors. Leveraging advanced technologies and strategic planning can help navigate these challenges and lead to successful therapeutic outcomes. Join Amanda as she discusses GenScript’s integrated technologies that will support your bispecific design, expression, and ensure your developability.