Resources

List by Alphabet: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

a Related Biological Terms:

AS-ODN

antisense oligodeoxyribonucleotide. (see antisense)

ASA

allele-specific amplification (see PCR amplification of specific alleles)ANDapolar water-accessible surface area

ASPCR

(= allele-specific PCR (ASPCR))

AT queue

A model that accounts for chromosomal banding. The microscopic appearance of chromosomes during mitosis (metaphase) displays chromomeres and interchromomeres, i.e. G bands (Giemsa stain) and R bands (Reverse) respectively; the former are characterized as AT-rich and gene-poor and by late replication, and the latter as GC- and gene-rich and by early replication. The DNA is presumably organized into wide spring-like coils from which 100kb G loops extend parallel to the chromosome axis (G bands), extended DNA sequences from which larger loops extend perpendicular to the chromosome axis (R loops), and AT-rich sequences called matrix-attachment or scaffold-associated regions that anchor the G and R loop regions and create the characteristically stained bands. Gardiner, K. (1995) Curr. Opin. genet. Dev. 5, 315-322

AT-AC intron

One of a minority of introns which have at their 5'- and 3'-termini, respectively, the AT and AC sequences. They are excised by a mechanism similar to that for the more common GU-AG introns.Nilsen, T.W. (1996) Science 273, 1813

ATPase

An enzyme that hydrolyses ATP; usually the partial activity of an enzyme, or system of enzymes, that uses the energy made available by the hydrolysis of ATP to drive an energetically unfavourable process, e.g. the Na+/K+-ATPase of cell membranes.

Abu shunt

An alternative pathway in bacteria and higher plants for entry of glutamate into the tricarboxylic acid cycle: glutamate-aminobutyrate (Abu) succinic acid semialdehyde succinate.

Achilles heel cleavage

A method for cleaving of DNA at very specific sequences. The site of cleavage is able to bind a specific protein, e.g. the lac repressor, that already contains a restriction site or is engineered to contain one; the presence of the DNA-binding protein protects the restriction site while the rest of the DNA is enzymically methylated, thus eliminating all unprotected restriction sites. Upon removal of the binding protein, the DNA can be cleaved at the one remaining restriction site. Roberts, L. (1990) Science 249, 127

Alu sequence

A small interespersed repeat element (SINE); a repetitive sequence in human DNA found in some introns, and characterized by Alu restriction sites; the locus of some homologous recombinations. Comprising 3-6% of the human genome, the sequences are about 300 bp long and usually feature a head-to-tail tandem repeat.Arcot, S.S., Adamson, A.W., Lamerdin, J.E., Kanagy, B., Deininger, P.L., Carrano, A.V. and Batzer, M.A. (1996) genome Res. 6, 1084-1092; Mighell, A.J., Markham, A.F. and Robinson, P.A. (1997) FEBS Lett. 417, 1-5

Alu-PCR

(see interspersed repetitive sequence-PCR (IRS-PCR))

< 1 2 3 4 5 6 7 > Total Pages 412

If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send detail to the Editorial Office at GenScript: website@genscript.com

If your term is adopted, we will send 1,000 EzCoupon points to your GenScript account.