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Hot Human Pathways

Click on a pathway below to view all genes and gene variants in the set.

Hot human pathway name Number of genes
Signal Transduction 2388
Metabolism 1628
Immune System 1361
Signaling by GPCR 1277
Gene Expression 1273
Metabolic pathways 1220
GPCR downstream signaling 975
Cell cycle 801
Innate Immune System 777
Metabolism of proteins 775
Disease 746
Developmental Biology 713
Adaptive Immune System 675
Axon guidance 644
Metabolism of lipids and lipoproteins 592
Transmembrane transport of small molecules 582
Generic Transcription Pathway 563
Cytokine Signaling in Immune system 543
Hemostasis 514
Cell Cycle, Mitotic 479
GPCR ligand binding 447
Signalling by NGF 432
Olfactory Signaling Pathway 425
MAPK signaling pathway 424
Gastrin-CREB signalling pathway via PKC and MAPK 424
Olfactory transduction 407
Signaling by Rho GTPases 401
Pathways in cancer 398
Cellular responses to stress 378
Fc epsilon receptor (FCERI) signaling 362
NGF signalling via TRKA from the plasma membrane 356
Post-translational protein modification 348
PI3K-Akt signaling pathway 347
Signaling by PDGF 346
DAP12 interactions 342
Signaling by EGFR 336
Signaling by Wnt 328
DAP12 signaling 326
Downstream signal transduction 323
Signaling by VEGF 321
Organelle biogenesis and maintenance 321
Signaling by ERBB2 321
Class A/1 (Rhodopsin-like receptors) 319
Signaling by FGFR 318
Signaling by FGFR2 317
Signaling by FGFR1 315
Signaling by FGFR4 314
Signaling by FGFR3 314
VEGFA-VEGFR2 Pathway 313
Hot human pathway name Number of genes
Signaling by ERBB4 313
Signaling by Interleukins 312
Downstream signaling of activated FGFR4 311
Downstream signaling of activated FGFR2 311
Downstream signaling of activated FGFR3 311
Downstream signaling of activated FGFR1 311
Signaling by SCF-KIT 308
Signaling by Insulin receptor 306
M Phase 298
MicroRNAs in cancer 297
Neuronal System 291
RHO GTPase Effectors 286
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 283
IGF1R signaling cascade 283
IRS-related events triggered by IGF1R 283
Insulin receptor signalling cascade 282
IRS-mediated signalling 279
MAPK family signaling cascades 274
Diseases of signal transduction 269
Metabolism of carbohydrates 268
Class I MHC mediated antigen processing & presentation 268
NCAM signaling for neurite out-growth 267
Extracellular matrix organization 267
FCERI mediated MAPK activation 267
Cytokine-cytokine receptor interaction 265
SLC-mediated transmembrane transport 263
GPCRs, Class A Rhodopsin-like 260
HTLV-I infection 259
Endocytosis 258
Vesicle-mediated transport 256
Chromatin modifying enzymes 256
Chromatin organization 256
Interleukin-3, 5 and GM-CSF signaling 255
Signalling to ERKs 247
Interleukin-2 signaling 246
VEGFR2 mediated cell proliferation 242
Signalling to RAS 240
Interleukin receptor SHC signaling 239
G alpha (i) signalling events 239
Signaling by Leptin 237
Prolonged ERK activation events 236
MAPK1/MAPK3 signaling 235
Frs2-mediated activation 234
Signalling to p38 via RIT and RIN 233
ARMS-mediated activation 233
TCF dependent signaling in response to WNT 231
B cell receptor signaling pathway 231
FRS-mediated FGFR4 signaling 230
SOS-mediated signalling 229
RAF/MAP kinase cascade 229