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SOX2 (SRY-box 2) gene, Homo sapiens

Do you need expression-ready SOX2 gene to study the functions and characteristics? GenScript offers SOX2 gene in any custom vector for your molecular biology studies by ordering SOX2 ORF clone.

About the SOX2 gene

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]

Genomic context of SOX2 gene

The human SOX2 gene is shown in the context of the human genome below. To see information about the SOX2 gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for mouse SOX2, rat SOX2, and human SOX2, as well as on-demand SOX2 ORF clones in other 183 species.

Chromosome 3 - NC_000003.12

Genomic sequence of SOX2 gene

Learn more about SOX2 gene

Bibliography

1.Increased SOX2 expression in salivary gland carcinoma ex pleomorphic adenoma progression: an association with adverse outcome.
Sedassari BT, et al. Virchows Arch, 2017 Dec. PMID 28842747

2.The influence of rAAV2-mediated SOX2 delivery into neonatal and adult human RPE cells; a comparative study.
Ezati R, et al. J Cell Physiol, 2018 Feb. PMID 28480968

3.Actinomycin D Down-regulates SOX2 Expression and Induces Death in Breast Cancer Stem Cells.
Das T, et al. Anticancer Res, 2017 Apr. PMID 28373426

4.Sox2 inhibits Wnt-β-catenin signaling and metastatic potency of cisplatin-resistant lung adenocarcinoma cells.
He J, et al. Mol Med Rep, 2017 Apr. PMID 28259951,

5.SOX2 Drives Bronchial Dysplasia in a Novel Organotypic Model of Early Human Squamous Lung Cancer.
Correia LL, et al. Am J Respir Crit Care Med, 2017 Jun 1. PMID 28199128,