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NCOR1 (Nuclear receptor corepressor 1) gene, Homo sapiens

Do you need expression-ready NCOR1 gene to study the functions and characteristics? GenScript offers NCOR1 gene in any custom vector for your molecular biology studies by ordering NCOR1 ORF clone.

About the NCOR1 gene

NCOR1 encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]

Genomic context of NCOR1 gene

The human NCOR1 gene is shown in the context of the human genome below. To see information about the NCOR1 gene in other species, please use the Search tool to select your desired species. GenScript has on-demand NCOR1 ORF clones in other 183 species.

Chromosome 17 - NC_000017.11

Genomic sequence of NCOR1 gene

Learn more about NCOR1 gene

Bibliography

1.Autoregulatory loop of nuclear corepressor 1 expression controls invasion, tumor growth, and metastasis.
Martínez-Iglesias OA, et al. Proc Natl Acad Sci U S A, 2016 Jan 19. PMID 26729869,

2.Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance.
Gallardo F, et al. Oncotarget, 2015 Apr 20. PMID 25823659,

3.NCoR controls glioblastoma tumor cell characteristics.
Heldring N, et al. Neuro Oncol, 2014 Jan. PMID 24335696,

4.Akt-induced phosphorylation of N-CoR at serine 1450 contributes to its misfolded conformational dependent loss (MCDL) in acute myeloid leukemia of the M5 subtype.
Nin DS, et al. PLoS One, 2013. PMID 23940660,