IRS-related events triggered by IGF1R
Homo sapiens (human) IRS-related events triggered by IGF1R (provided by Reactome)
About the IRS-related events triggered by IGF1R pathway
The phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, Siddle et al. 2012). The phosphorylated IRS proteins serve as scaffolds that bind the effector molecules PI3K and GRB2:SOS. PI3K then activates PKB (AKT) signaling while GRB2:SOS activates RAS-RAF-MAPK signaling.
The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.
283 gene
| Gene Symbol | Full Name |
|---|---|
| ACTN2 | actinin, alpha 2 |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 |
| ANGPT1 | angiopoietin 1 |
| ARAF | A-Raf proto-oncogene, serine/threonine kinase |
| ARRB1 | arrestin, beta 1 |
| ARRB2 | arrestin, beta 2 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase |
| BTC | betacellulin |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) |
| CALM3 | calmodulin 3 (phosphorylase kinase, delta) |
| CAMK2A | calcium/calmodulin-dependent protein kinase II alpha |
| CAMK2B | calcium/calmodulin-dependent protein kinase II beta |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta |
| CAMK2G | calcium/calmodulin-dependent protein kinase II gamma |
| CSF2 | colony stimulating factor 2 (granulocyte-macrophage) |
| CSF2RA | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) |
| CSK | c-src tyrosine kinase |
| DLG4 | discs, large homolog 4 (Drosophila) |
| HBEGF | heparin-binding EGF-like growth factor |
| DUSP1 | dual specificity phosphatase 1 |
| DUSP2 | dual specificity phosphatase 2 |
| DUSP4 | dual specificity phosphatase 4 |
| DUSP5 | dual specificity phosphatase 5 |
| DUSP6 | dual specificity phosphatase 6 |
| DUSP7 | dual specificity phosphatase 7 |
| DUSP8 | dual specificity phosphatase 8 |
| DUSP9 | dual specificity phosphatase 9 |
| EGF | epidermal growth factor |
| EGFR | epidermal growth factor receptor |
| EIF4B | eukaryotic translation initiation factor 4B |
| EIF4E | eukaryotic translation initiation factor 4E |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 |
| EREG | epiregulin |
| FGA | fibrinogen alpha chain |
| FGB | fibrinogen beta chain |
| FGF1 | fibroblast growth factor 1 (acidic) |
| FGF2 | fibroblast growth factor 2 (basic) |
| FGF3 | fibroblast growth factor 3 |
| FGF4 | fibroblast growth factor 4 |
| FGF5 | fibroblast growth factor 5 |
| FGF6 | fibroblast growth factor 6 |
| FGF7 | fibroblast growth factor 7 |
| FGF8 | fibroblast growth factor 8 (androgen-induced) |
| FGF9 | fibroblast growth factor 9 |
| FGF10 | fibroblast growth factor 10 |
| FGFR1 | fibroblast growth factor receptor 1 |
| FGFR3 | fibroblast growth factor receptor 3 |
| FGFR2 | fibroblast growth factor receptor 2 |
| FGFR4 | fibroblast growth factor receptor 4 |
| FGG | fibrinogen gamma chain |
| FN1 | fibronectin 1 |
| MTOR | mechanistic target of rapamycin (serine/threonine kinase) |
| FYN | FYN proto-oncogene, Src family tyrosine kinase |
| GAB1 | GRB2-associated binding protein 1 |
| GRB2 | growth factor receptor-bound protein 2 |
| GRIN1 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B |
| GRIN2C | glutamate receptor, ionotropic, N-methyl D-aspartate 2C |
| GRIN2D | glutamate receptor, ionotropic, N-methyl D-aspartate 2D |
| NRG1 | neuregulin 1 |
| HRAS | Harvey rat sarcoma viral oncogene homolog |
| IGF1 | insulin-like growth factor 1 (somatomedin C) |
| IGF1R | insulin-like growth factor 1 receptor |
| IGF2 | insulin-like growth factor 2 |
| IL2 | interleukin 2 |
| IL2RA | interleukin 2 receptor, alpha |
| IL2RB | interleukin 2 receptor, beta |
| IL2RG | interleukin 2 receptor, gamma |
| IL3 | interleukin 3 |
| IL3RA | interleukin 3 receptor, alpha (low affinity) |
| IL5 | interleukin 5 |
| IL5RA | interleukin 5 receptor, alpha |
| IRS1 | insulin receptor substrate 1 |
| ITGA2B | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
| JAK1 | Janus kinase 1 |
| JAK2 | Janus kinase 2 |
| JAK3 | Janus kinase 3 |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| KRAS | Kirsten rat sarcoma viral oncogene homolog |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 |
| KITLG | KIT ligand |
| MAP3K11 | mitogen-activated protein kinase kinase kinase 11 |
| NCAM1 | neural cell adhesion molecule 1 |
| NEFL | neurofilament, light polypeptide |
| NF1 | neurofibromin 1 |
| NRAS | neuroblastoma RAS viral (v-ras) oncogene homolog |
| PEBP1 | phosphatidylethanolamine binding protein 1 |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited |
| PDGFA | platelet-derived growth factor alpha polypeptide |
| PDGFB | platelet-derived growth factor beta polypeptide |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide |
