Interleukin-2 signaling
Homo sapiens (human) Interleukin-2 signaling (provided by Reactome)
About the Interleukin-2 signaling pathway
Interleukin-2 (IL-2) is a cytokine that is produced by T cells in response to antigen stimulation. Originally, IL-2 was discovered because of its potent growth factor activity on activated T cells in vitro and was therefore named 'T cell growth factor' (TCGF). However, the generation of IL-2- and IL-2 receptor-deficient mice revealed that IL-2 also plays a regulatory role in the immune system by suppressing autoimmune responses. Two main mechanisms have been identified that explain this suppressive function: (1) IL-2 sensitizes activated T cells for activation-induced cell death (AICD) and (2) IL-2 is critical for the survival and function of regulatory T cells (Tregs), which possess potent immunosuppressive properties.
The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.
246 gene
| Gene Symbol | Full Name |
|---|---|
| ACTN2 | actinin, alpha 2 |
| ANGPT1 | angiopoietin 1 |
| ARAF | A-Raf proto-oncogene, serine/threonine kinase |
| ARRB1 | arrestin, beta 1 |
| ARRB2 | arrestin, beta 2 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase |
| BTC | betacellulin |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) |
| CALM3 | calmodulin 3 (phosphorylase kinase, delta) |
| CAMK2A | calcium/calmodulin-dependent protein kinase II alpha |
| CAMK2B | calcium/calmodulin-dependent protein kinase II beta |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta |
| CAMK2G | calcium/calmodulin-dependent protein kinase II gamma |
| CSF2 | colony stimulating factor 2 (granulocyte-macrophage) |
| CSF2RA | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) |
| CSK | c-src tyrosine kinase |
| DLG4 | discs, large homolog 4 (Drosophila) |
| HBEGF | heparin-binding EGF-like growth factor |
| DUSP1 | dual specificity phosphatase 1 |
| DUSP2 | dual specificity phosphatase 2 |
| DUSP4 | dual specificity phosphatase 4 |
| DUSP5 | dual specificity phosphatase 5 |
| DUSP6 | dual specificity phosphatase 6 |
| DUSP7 | dual specificity phosphatase 7 |
| DUSP8 | dual specificity phosphatase 8 |
| DUSP9 | dual specificity phosphatase 9 |
| EGF | epidermal growth factor |
| EGFR | epidermal growth factor receptor |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 |
| EREG | epiregulin |
| PTK2B | protein tyrosine kinase 2 beta |
| FGA | fibrinogen alpha chain |
| FGB | fibrinogen beta chain |
| FGF1 | fibroblast growth factor 1 (acidic) |
| FGF2 | fibroblast growth factor 2 (basic) |
| FGF3 | fibroblast growth factor 3 |
| FGF4 | fibroblast growth factor 4 |
| FGF5 | fibroblast growth factor 5 |
| FGF6 | fibroblast growth factor 6 |
| FGF7 | fibroblast growth factor 7 |
| FGF8 | fibroblast growth factor 8 (androgen-induced) |
| FGF9 | fibroblast growth factor 9 |
| FGF10 | fibroblast growth factor 10 |
| FGFR1 | fibroblast growth factor receptor 1 |
| FGFR3 | fibroblast growth factor receptor 3 |
| FGFR2 | fibroblast growth factor receptor 2 |
| FGFR4 | fibroblast growth factor receptor 4 |
| FGG | fibrinogen gamma chain |
| FN1 | fibronectin 1 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase |
| GRB2 | growth factor receptor-bound protein 2 |
| GRIN1 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B |
| GRIN2C | glutamate receptor, ionotropic, N-methyl D-aspartate 2C |
| GRIN2D | glutamate receptor, ionotropic, N-methyl D-aspartate 2D |
| NRG1 | neuregulin 1 |
| HRAS | Harvey rat sarcoma viral oncogene homolog |
| IL2 | interleukin 2 |
| IL2RA | interleukin 2 receptor, alpha |
| IL2RB | interleukin 2 receptor, beta |
| IL2RG | interleukin 2 receptor, gamma |
| IL3 | interleukin 3 |
| IL3RA | interleukin 3 receptor, alpha (low affinity) |
| IL5 | interleukin 5 |
| IL5RA | interleukin 5 receptor, alpha |
| INPP5D | inositol polyphosphate-5-phosphatase D |
| INPPL1 | inositol polyphosphate phosphatase-like 1 |
| IRS1 | insulin receptor substrate 1 |
| ITGA2B | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
| JAK1 | Janus kinase 1 |
| JAK2 | Janus kinase 2 |
| JAK3 | Janus kinase 3 |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| KRAS | Kirsten rat sarcoma viral oncogene homolog |
| LCK | LCK proto-oncogene, Src family tyrosine kinase |
| LGALS9 | lectin, galactoside-binding, soluble, 9 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 |
| KITLG | KIT ligand |
| MAP3K11 | mitogen-activated protein kinase kinase kinase 11 |
| NCAM1 | neural cell adhesion molecule 1 |
| NEFL | neurofilament, light polypeptide |
| NF1 | neurofibromin 1 |
| NRAS | neuroblastoma RAS viral (v-ras) oncogene homolog |
| PEBP1 | phosphatidylethanolamine binding protein 1 |
| PDGFA | platelet-derived growth factor alpha polypeptide |
| PDGFB | platelet-derived growth factor beta polypeptide |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide |
| PHB | prohibitin |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
| PIK3CB | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta |
| PIK3CD | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
| PIK3R2 | phosphoinositide-3-kinase, regulatory subunit 2 (beta) |
