Chromatin modifying enzymes
Homo sapiens (human) Chromatin modifying enzymes (provided by Reactome)
About the Chromatin modifying enzymes pathway
Eukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect it from damage. Access to DNA is achieved by highly regulated local chromatin decondensation. The 'building block' of chromatin is the nucleosome. This contains ~150 bp of DNA wrapped around a histone octamer which consists of two each of the core histones H2A, H2B, H3 and H4 in a 1.65 left-handed superhelical turn (Luger et al. 1997, Andrews & Luger 2011).
The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.
256 gene
| Gene Symbol | Full Name |
|---|---|
| ACTB | actin, beta |
| ACTL6A | actin-like 6A |
| CCND1 | cyclin D1 |
| CDK4 | cyclin-dependent kinase 4 |
| CHD3 | chromodomain helicase DNA binding protein 3 |
| CHD4 | chromodomain helicase DNA binding protein 4 |
| ATF2 | activating transcription factor 2 |
| CREBBP | CREB binding protein |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha |
| DR1 | down-regulator of transcription 1 |
| EP300 | E1A binding protein p300 |
| MECOM | MDS1 and EVI1 complex locus |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit |
| KAT2A | K(lysine) acetyltransferase 2A |
| GPS2 | G protein pathway suppressor 2 |
| HIST1H2AE | histone cluster 1, H2ae |
| HIST1H2AD | histone cluster 1, H2ad |
| H2AFX | H2A histone family, member X |
| H2AFZ | H2A histone family, member Z |
| HIST1H2BD | histone cluster 1, H2bd |
| HIST1H2BB | histone cluster 1, H2bb |
| HCFC1 | host cell factor C1 |
| HDAC1 | histone deacetylase 1 |
| HDAC2 | histone deacetylase 2 |
| PRMT1 | protein arginine methyltransferase 1 |
| JAK2 | Janus kinase 2 |
| KMT2A | lysine (K)-specific methyltransferase 2A |
| PAX3 | paired box 3 |
| PHF2 | PHD finger protein 2 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) |
| KDM5A | lysine (K)-specific demethylase 5A |
| RBBP4 | retinoblastoma binding protein 4 |
| RBBP5 | retinoblastoma binding protein 5 |
| RBBP7 | retinoblastoma binding protein 7 |
| REST | RE1-silencing transcription factor |
| ATXN7 | ataxin 7 |
| SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
| SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 |
| SMARCB1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 |
| SMARCD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 |
| SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 |
| SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| TADA2A | transcriptional adaptor 2A |
| TAF9 | TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa |
| TAF10 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa |
| TAF12 | TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa |
| TBL1X | transducin (beta)-like 1X-linked |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) |
| KDM6A | lysine (K)-specific demethylase 6A |
| WHSC1 | Wolf-Hirschhorn syndrome candidate 1 |
| BRPF1 | bromodomain and PHD finger containing, 1 |
| KAT6A | K(lysine) acetyltransferase 6A |
| KMT2D | lysine (K)-specific methyltransferase 2D |
| YEATS4 | YEATS domain containing 4 |
| KDM5C | lysine (K)-specific demethylase 5C |
| KDM5D | lysine (K)-specific demethylase 5D |
| ARID1A | AT rich interactive domain 1A (SWI-like) |
| HIST1H4I | histone cluster 1, H4i |
| TRRAP | transformation/transcription domain-associated protein |
| HIST1H2AI | histone cluster 1, H2ai |
| HIST1H2AK | histone cluster 1, H2ak |
| HIST1H2AJ | histone cluster 1, H2aj |
| HIST1H2AL | histone cluster 1, H2al |
| HIST1H2AC | histone cluster 1, H2ac |
| HIST1H2AB | histone cluster 1, H2ab |
| HIST1H2AM | histone cluster 1, H2am |
| HIST2H2AA3 | histone cluster 2, H2aa3 |
| HIST2H2AC | histone cluster 2, H2ac |
| HIST1H2BG | histone cluster 1, H2bg |
| HIST1H2BL | histone cluster 1, H2bl |
| HIST1H2BN | histone cluster 1, H2bn |
| HIST1H2BM | histone cluster 1, H2bm |
| HIST1H2BF | histone cluster 1, H2bf |
| HIST1H2BE | histone cluster 1, H2be |
| HIST1H2BH | histone cluster 1, H2bh |
| HIST1H2BI | histone cluster 1, H2bi |
| HIST1H2BC | histone cluster 1, H2bc |
| HIST1H2BO | histone cluster 1, H2bo |
| HIST2H2BE | histone cluster 2, H2be |
| HIST1H3A | histone cluster 1, H3a |
| HIST1H3D | histone cluster 1, H3d |
| HIST1H3C | histone cluster 1, H3c |
| HIST1H3E | histone cluster 1, H3e |
| HIST1H3I | histone cluster 1, H3i |
| HIST1H3G | histone cluster 1, H3g |
| HIST1H3J | histone cluster 1, H3j |
| HIST1H3H | histone cluster 1, H3h |
| HIST1H3B | histone cluster 1, H3b |
| HIST1H4A | histone cluster 1, H4a |
| HIST1H4D | histone cluster 1, H4d |
| HIST1H4F | histone cluster 1, H4f |
| HIST1H4K | histone cluster 1, H4k |
| HIST1H4J | histone cluster 1, H4j |
| HIST1H4C | histone cluster 1, H4c |
| HIST1H4H | histone cluster 1, H4h |
| HIST1H4B | histone cluster 1, H4b |
