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GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) gene, Homo sapiens

Do you need expression-ready GAPDH gene to study the functions and characteristics? GenScript offers GAPDH gene in any custom vector for your molecular biology studies by ordering GAPDH ORF clone.

About the GAPDH gene

GAPDH encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Genomic context of GAPDH gene

The human GAPDH gene is shown in the context of the human genome below. To see information about the GAPDH gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for mouse GAPDH, rat GAPDH, and human GAPDH, as well as on-demand GAPDH ORF clones in other 183 species.

Chromosome 12 - NC_000012.12

Genomic sequence of GAPDH gene

Learn more about GAPDH gene

Bibliography

1.Role of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) in DNA Repair.
Kosova AA, et al. Biochemistry (Mosc), 2017 Jun. PMID 28601074

2.A hydrocortisone derivative binds to GAPDH and reduces the toxicity of extracellular polyglutamine-containing aggregates.
Lazarev VF, et al. Biochem Biophys Res Commun, 2017 Jun 3. PMID 28450110

3.Interaction of glyceraldehyde-3-phosphate dehydrogenase and heme: The relevance of its biological function.
Huang Y, et al. Arch Biochem Biophys, 2017 Apr 1. PMID 28315300

4.Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Aggregation Causes Mitochondrial Dysfunction during Oxidative Stress-induced Cell Death.
Nakajima H, et al. J Biol Chem, 2017 Mar 17. PMID 28167533,

5.Monoclonal Antibodies DSHB-hGAPDH-2G7 and DSHB-hGAPDH-4B7 Against Human Glyceraldehyde-3-Phosphate Dehydrogenase.
Monoclon Antib Immunodiagn Immunother, 2016 Aug. PMID 27556912