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FMO3 (Flavin containing monooxygenase 3) gene, Homo sapiens

Do you need expression-ready FMO3 gene to study the functions and characteristics? GenScript offers FMO3 gene in any custom vector for your molecular biology studies by ordering FMO3 ORF clone.

About the FMO3 gene

Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Jan 2016]

Genomic context of FMO3 gene

The human FMO3 gene is shown in the context of the human genome below. To see information about the FMO3 gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for mouse FMO3, rat FMO3, and human FMO3, as well as on-demand FMO3 ORF clones in other 183 species.

Chromosome 1 - NC_000001.11

Genomic sequence of FMO3 gene

Learn more about FMO3 gene

Bibliography

1.Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway.
El-Serafi I, et al. PLoS One, 2017. PMID 29121650

2.Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.
Xu M, et al. J Pharmacol Exp Ther, 2017 Nov. PMID 28819071,

3.Effects of FMO3 Polymorphisms on Pharmacokinetics of Sulindac in Chinese Healthy Male Volunteers.
Tang YJ, et al. Biomed Res Int, 2017. PMID 28331852,

4.Human flavin-containing monooxygenase 3: Structural mapping of gene polymorphisms and insights into molecular basis of drug binding.
Gao C, et al. Gene, 2016 Nov 15. PMID 27523475

5.Association of FMO3 Variants and Trimethylamine N-Oxide Concentration, Disease Progression, and Mortality in CKD Patients.
Robinson-Cohen C, et al. PLoS One, 2016. PMID 27513517,