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EPO (Erythropoietin) gene, Homo sapiens

Do you need expression-ready EPO gene to study the functions and characteristics? GenScript offers EPO gene in any custom vector for your molecular biology studies by ordering EPO ORF clone.

About the EPO gene

EPO encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies. [provided by RefSeq, Aug 2017]

Genomic context of EPO gene

The human EPO gene is shown in the context of the human genome below. To see information about the EPO gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for mouse EPO, rat EPO, and human EPO, as well as on-demand EPO ORF clones in other 183 species.

Chromosome 7 - NC_000007.14

Genomic sequence of EPO gene

Learn more about EPO gene

Bibliography

1.Effect of quercetin on cell protection via erythropoietin and cell injury of HepG2 cells.
Nishimura K, et al. Arch Biochem Biophys, 2017 Dec 15. PMID 29080630

2.Erythropoietin Induces an Epithelial to Mesenchymal Transition-Like Process in Mammary Epithelial Cells MCF10A.
Ordoñez-Moreno A, et al. J Cell Biochem, 2017 Sep. PMID 28247960

3.Molecular Design, Expression and Evaluation of PASylated Human Recombinant Erythropoietin with Enhanced Functional Properties.
Hedayati MH, et al. Protein J, 2017 Feb. PMID 28168382

4.Erythropoietin in Predicting Prognosis in Patients with Acute-on-Chronic Liver Failure.
Alempijevic T, et al. J Gastrointestin Liver Dis, 2016 Dec. PMID 27981303

5.Erythropoietin induces production of hepatocyte growth factor from bone marrow mesenchymal stem cells in vitro.
Tari K, et al. Biologicals, 2017 Jan. PMID 27865586