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BDNF (Brain-Derived Neurotrophic Factor) gene , Homo sapiens

Do you need expression-ready BDNF gene to study the functions and characteristics? GenScript offers BCL2 gene in any custom vector for your molecular biology studies by ordering an BDNF ORF clone.

About the BDNF gene

BDNF gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]

Genomic context of BDNF gene

The human BDNF gene is shown in the context of the human genome below. To see information about the BDNF gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for human BDNF and mouse BDNF , as well as on-demand BDNF ORF clones in 183 other species.

Chromosome 11 - NC_000011.10

Genomic sequence of BDNF gene

Learn more about BDNF gene

Bibliography

1.Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort.
Jiang R, et al. Am Heart J, 2017 Aug. PMID 28760212

2.Evidence of associations between brain-derived neurotrophic factor (BDNF) serum levels and gene polymorphisms with tinnitus.
Coskunoglu A, et al. Noise Health, 2017 May-Jun. PMID 28615544

3.Increased serum brain-derived neurotrophic factor in male schizophrenic patients with metabolic syndrome.
Lin CC, et al. Medicine (Baltimore), 2017 Jun. PMID 28562580

4.Brain-derived neurotrophic factor and airway fibrosis in asthma.
Freeman MR, et al. Am J Physiol Lung Cell Mol Physiol, 2017 Aug 1. PMID 28522569

5.Association Between Brain-Derived Neurotrophic Factor Genotype and Upper Extremity Motor Outcome After Stroke.
Chang WH, et al. Stroke, 2017 Jun. PMID 28495829