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Entrez Gene ID (e.g. 7157)
gene symbol (e.g. TP53)
gene name (e.g. tumor protein p53)
gene synonyms (e.g. FLJ92943)
Ensembl ID (e.g. ENSG0000141510)
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BCL2 gene (B-Cell CLL/Lymphoma 2) gene, Homo sapiens

Do you need expression-ready BCL2 gene to study the functions and characteristics? GenScript offers BCL2 gene in any custom vector for your molecular biology studies by ordering an BCL2 ORF clone.

About the BCL2 gene

BCL2 gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Genomic context of BCL2 gene

The human BCL2 gene is shown in the context of the human genome below. To see information about the BCL2 gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for human BCL2 and mouse BCL2, as well as on-demand BCL2 ORF clones in 183 other species.

Chromosome 18 - NC_000018.10

Genomic sequence of BCL2 gene

Learn more about BCL2 gene

Bibliography

1.Induction of the chromosomal translocation t(14;18) by targeting the BCL-2 locus with specific binding I-125-labeled triplex-forming oligonucleotides.
Dahmen V, et al. Mutat Res, 2017 Nov. PMID 28985947

2.BCL2 expression in DLBCL: reappraisal of immunohistochemistry with new criteria for therapeutic biomarker evaluation.
Tsuyama N, et al. Blood, 2017 Jul 27. PMID 28522442

3.Two Distinct BCL2 Rearrangements, Each Observed in 2 Independent Subclones, Evolving from a Founder Clone with Trisomy 12 in a Unique Case of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.
Peterson JF, et al. Acta Haematol, 2017. PMID 28514780