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ATIC (5-Aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase) gene, Homo sapiens

Do you need expression-ready ATIC gene to study the functions and characteristics? GenScript offers ATIC gene in any custom vector for your molecular biology studies by ordering ATIC ORF clone.

About the ATIC gene

ATIC encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]

Genomic context of ATIC gene

The human ATIC gene is shown in the context of the human genome below. To see information about the ATIC gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for mouse ATIC, rat ATIC, and human ATIC, as well as on-demand ATIC ORF clones in other 183 species.

Chromosome 2 - NC_000002.12

Genomic sequence of ATIC gene

Learn more about ATIC gene

Bibliography

1.ATIC Gene Polymorphism and Histologic Response to Chemotherapy in Pediatric Osteosarcoma.
Park JA, et al. J Pediatr Hematol Oncol, 2017 Jul. PMID 28267080

2.Association of the ATIC 347 C/G polymorphism with responsiveness to and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis.
Lee YH, et al. Rheumatol Int, 2016 Nov. PMID 27379764

3.ATIC 347C>G gene polymorphism may be associated with methotrexate-induced adverse events in south Indian Tamil rheumatoid arthritis.
Muralidharan N, et al. Pharmacogenomics, 2016 Feb. PMID 26799664

4.The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling.
Bulock KG, et al. J Biol Chem, 2002 Jun 21. PMID 11948179

5.Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity.
Vergis JM, et al. J Biol Chem, 2001 Mar 16. PMID 11096114