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AKT1 (V-Akt Murine Thymoma Viral Oncogene Homolog 1) gene, Homo sapiens

Do you need expression-ready AKT1 gene to study the functions and characteristics? GenScript offers AKT1 gene in any custom vector for your molecular biology studies by ordering an AKT1 ORF clone.

About the AKT1 gene

AKT1 gene encodes a serine-threonine protein kinase, which is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]

Genomic context of AKT1 gene

The human AKT1 gene is shown in the context of the human genome below. To see information about the AKT1 gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for human AKT1 and mouse AKT1, as well as on-demand AKT1 ORF clones in 183 other species.

Chromosome 14 - NC_000014.9

Genomic sequence of AKT1 gene

Learn more about AKT1 gene

Bibliography

1.Lysophosphatidylcholine activates the Akt pathway to upregulate extracellular matrix protein production in human aortic valve cells.
Cheng H, et al. J Surg Res, 2017 Jun 1. PMID 28601321

2.AKT Inhibition in Solid Tumors With AKT1 Mutations.
Hyman DM, et al. J Clin Oncol, 2017 Jul 10. PMID 28489509

3.Accurate detection of low prevalence AKT1 E17K mutation in tissue or plasma from advanced cancer patients.
de Bruin EC, et al. PLoS One, 2017. PMID 28472036, Free PMC Article

4.Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han population.
Liu JM, et al. Genet Mol Res, 2017 Mar 30. PMID 28363000

5.Intracellular calcium promotes radioresistance of non-small cell lung cancer A549 cells through activating Akt signaling.
Wang Y, et al. Tumour Biol, 2017 Mar. PMID 28351325