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Your can enter the following as search terms:
- Entrez Gene ID (e.g. 7157)
- gene symbol (e.g. TP53)
- gene name (e.g. tumor protein p53)
- gene synonyms (e.g. FLJ92943)
- Ensembl ID (e.g. ENSG0000141510)
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- Species can be input after the keyword, using format "keyword [species:$species]" where $species can be name of species (like human or rat) or taxon id (like 9606).
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ACTN3 (actin alpha 3) gene, Homo sapiens
Do you need expression-ready ACTN3 gene to study the functions and characteristics? GenScript offers ACTN3 gene in any custom vector for your molecular biology studies by ordering an ACTN3 ORF clone.
About the ACTN3 gene
ACTN3 gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the coding allele. The non-functional allele of this gene is associated with elite athlete status. [provided by RefSeq, Feb 2014].
Genomic context of ACTN3 gene
The human ACTN3 gene is shown in the context of the human genome below. To see information about the ACTN3 gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for mouse ACTN3 , rat ACTN3 , and human ACTN3 , as well as on-demand ACTN3 ORF clones in other 183 species.
Chromosome 11 - NC_000011.10
Genomic sequence of ACTN3 gene
Bibliography
1.Association between ACTN3 R577X Polymorphism and Trunk Flexibility in 2 Different Cohorts.
Kikuchi N, et al. Int J Sports Med, 2017 May. PMID 28303562
2.The influence of α-actinin-3 deficiency on bone remodelling markers in young men.
Levinger I, et al. Bone, 2017 May. PMID 28254467
3.ACTN3 genotype influences exercise-induced muscle damage during a marathon competition.
Del Coso J, et al. Eur J Appl Physiol, 2017 Mar. PMID 28154975
4.Genetic association between ACTN3 polymorphism and risk of non-acute ankle sprain.
Qi B, et al. Genet Mol Res, 2016 Dec 2. PMID 27966742
5.ACTN3 X-allele carriers had greater levels of muscle damage during a half-ironman.
Del Coso J, et al. Eur J Appl Physiol, 2017 Jan. PMID 27913923
