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complexity

In nucleic acid chemistry, a measure of the unique sequences in a DNA preparation; it increases with chain length and decreases with the extent to which the sequences are repetitive; evaluated as the size of a DNA fragment with no repetitive sequences that has the same Cot½ value. In protein chemistry it is a quantitative measure of the randomness of a polypeptide sequence, C, which ranges from 0 for a homopolymer to 1.0 for a perfectly random sequence. For example, the complexity of collagen is 0.23 and that of globular proteins is about 0.90; C= fi ln (fi), where fi is the mol fraction of amino acid i among all the amino acids represented in the protein. (see also Cot unit; simplified)Clarke, N.D. (1995) Curr. Opin. Biotechnol. 6, 467-472

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