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immunoglobulin gene

A gene en coding one of the protein chains (light or heavy) of an immunoglobulin. The germline genes are activated by a special recombination process that joins a number of different gene segments together. In the case of immunoglobulin light chains there are three segments (V variable, J joining and C constant). In the case of immunoglobulin heavy chains there are four segments (V variable, D diversity, J joining and C constant). There are many different V segments (light chains ~300, heavy chains ~500), 4 J segments in both light and heavy chain genes, 12 D segments in the heavy chain gene and 1 C segment in light chain genes, 5 C segments in heavy chain gene. The recombination process appears to be able to join any V with any J (light chain) or any V to D to J (heavy chain). The total number of possible immunoglobulins (ie the number of possible light chains times the number of possible heavy chains) that can be generated by this mechanism is thus several 10s of millions (300x4x500x12x4=28800000). It is certain that the number is greater than this because the recombination events themselves are not precise and random loss of nucleotides from each recombining end occurs.

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